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Robust control of HIV infection by antiretroviral therapy: a super‐twisting sliding mode control approach
Acquired immune deficiency syndrome is an epidemic infectious disease which is caused by the human immunodeficiency virus (HIV) and that has proliferated across worldwide. It has been a matter of concern for the scientific community to develop an antiretroviral therapy, which will prompt a rapid dec...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Institution of Engineering and Technology
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687324/ https://www.ncbi.nlm.nih.gov/pubmed/31170691 http://dx.doi.org/10.1049/iet-syb.2018.5063 |
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author | Bera, Manas Kumar Kumar, Pintu Biswas, Raj Kumar |
author_facet | Bera, Manas Kumar Kumar, Pintu Biswas, Raj Kumar |
author_sort | Bera, Manas Kumar |
collection | PubMed |
description | Acquired immune deficiency syndrome is an epidemic infectious disease which is caused by the human immunodeficiency virus (HIV) and that has proliferated across worldwide. It has been a matter of concern for the scientific community to develop an antiretroviral therapy, which will prompt a rapid decline in viral abundance. With this motivation, this study proposes the design of a robust super twisting sliding mode controller based on output information for an uncertain HIV infection model. The control objective is to decrease the concentration of infected CD4+ T cells to a specified level by drug administration using only the output information of the uncertain HIV infection model which is total CD4+ T cell concentration. The robust output‐feedback controller has been developed in combination with a robust exact differentiator, functioning as an observer. The reported analysis demonstrates that the approach proposed here is capable of ensuring robust performance under several operating conditions, measurement and modelling error, parametric uncertainties and external disturbances and the simulation results prove the proficiency of the controller proposed. |
format | Online Article Text |
id | pubmed-8687324 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Institution of Engineering and Technology |
record_format | MEDLINE/PubMed |
spelling | pubmed-86873242022-02-16 Robust control of HIV infection by antiretroviral therapy: a super‐twisting sliding mode control approach Bera, Manas Kumar Kumar, Pintu Biswas, Raj Kumar IET Syst Biol Research Article Acquired immune deficiency syndrome is an epidemic infectious disease which is caused by the human immunodeficiency virus (HIV) and that has proliferated across worldwide. It has been a matter of concern for the scientific community to develop an antiretroviral therapy, which will prompt a rapid decline in viral abundance. With this motivation, this study proposes the design of a robust super twisting sliding mode controller based on output information for an uncertain HIV infection model. The control objective is to decrease the concentration of infected CD4+ T cells to a specified level by drug administration using only the output information of the uncertain HIV infection model which is total CD4+ T cell concentration. The robust output‐feedback controller has been developed in combination with a robust exact differentiator, functioning as an observer. The reported analysis demonstrates that the approach proposed here is capable of ensuring robust performance under several operating conditions, measurement and modelling error, parametric uncertainties and external disturbances and the simulation results prove the proficiency of the controller proposed. The Institution of Engineering and Technology 2019-06-01 /pmc/articles/PMC8687324/ /pubmed/31170691 http://dx.doi.org/10.1049/iet-syb.2018.5063 Text en © 2020 The Institution of Engineering and Technology https://creativecommons.org/licenses/by-nd/3.0/This is an open access article published by the IET under the Creative Commons Attribution‐NoDerivs License (http://creativecommons.org/licenses/by-nd/3.0/ (https://creativecommons.org/licenses/by-nd/3.0/) ) |
spellingShingle | Research Article Bera, Manas Kumar Kumar, Pintu Biswas, Raj Kumar Robust control of HIV infection by antiretroviral therapy: a super‐twisting sliding mode control approach |
title | Robust control of HIV infection by antiretroviral therapy: a super‐twisting sliding mode control approach |
title_full | Robust control of HIV infection by antiretroviral therapy: a super‐twisting sliding mode control approach |
title_fullStr | Robust control of HIV infection by antiretroviral therapy: a super‐twisting sliding mode control approach |
title_full_unstemmed | Robust control of HIV infection by antiretroviral therapy: a super‐twisting sliding mode control approach |
title_short | Robust control of HIV infection by antiretroviral therapy: a super‐twisting sliding mode control approach |
title_sort | robust control of hiv infection by antiretroviral therapy: a super‐twisting sliding mode control approach |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687324/ https://www.ncbi.nlm.nih.gov/pubmed/31170691 http://dx.doi.org/10.1049/iet-syb.2018.5063 |
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