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Use of Thyroid Hormones in Hypothyroid and Euthyroid Patients: A 2020 THESIS Questionnaire Survey of Members of the Swedish Endocrine Society

BACKGROUND: The standard treatment of hypothyroidism is levothyroxine (LT-4). However, there are several controversies regarding treatment of hypothyroid patients. AIM: To investigate the Swedish endocrinologists’ use of thyroid hormones in hypothyroid and euthyroid individuals. METHODS: Physician m...

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Detalles Bibliográficos
Autores principales: Planck, Tereza, Lantz, Mikael, Perros, Petros, Papini, Enrico, Attanasio, Roberto, Nagy, Endre V., Hegedüs, Laszlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687360/
https://www.ncbi.nlm.nih.gov/pubmed/34938274
http://dx.doi.org/10.3389/fendo.2021.795111
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author Planck, Tereza
Lantz, Mikael
Perros, Petros
Papini, Enrico
Attanasio, Roberto
Nagy, Endre V.
Hegedüs, Laszlo
author_facet Planck, Tereza
Lantz, Mikael
Perros, Petros
Papini, Enrico
Attanasio, Roberto
Nagy, Endre V.
Hegedüs, Laszlo
author_sort Planck, Tereza
collection PubMed
description BACKGROUND: The standard treatment of hypothyroidism is levothyroxine (LT-4). However, there are several controversies regarding treatment of hypothyroid patients. AIM: To investigate the Swedish endocrinologists’ use of thyroid hormones in hypothyroid and euthyroid individuals. METHODS: Physician members of the Swedish Endocrine Society (SEF) were invited by e-mail to participate in an online survey investigating this topic. RESULTS: Out of the eligible 411 members, 116 (28.2%) responded. The majority (98.9%) stated that L-T4 is the treatment of choice. However, around 50% also prescribed liothyronine (L-T3) or a combination of L-T4+L-T3 in their practice. Combination therapy was mostly (78.5%) used in patients with persistent hypothyroid symptoms despite biochemical euthyroidism on L-T4 treatment. Most respondents prescribed L-T4 tablets and did not expect any major changes with alternative formulations such as soft-gel capsules or liquid formulations in situations influencing the bioavailability of L-T4. In euthyroid patients, 49.5% replied that treatment with thyroid hormones was never indicated, while 47.3% would consider L-T4 for euthyroid infertile women with high thyroid peroxidase (TPO) antibody levels. CONCLUSION: The treatment of choice for hypothyroidism in Sweden is L-T4 tablets. Combination therapy with L-T4+L-T3 tablets was considered for patients with persistent symptoms despite biochemical euthyroidism. Soft-gel capsules and liquid solutions of L-T4 were infrequently prescribed. Swedish endocrinologists’ deviation from endocrine society guidelines merits further study.
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spelling pubmed-86873602021-12-21 Use of Thyroid Hormones in Hypothyroid and Euthyroid Patients: A 2020 THESIS Questionnaire Survey of Members of the Swedish Endocrine Society Planck, Tereza Lantz, Mikael Perros, Petros Papini, Enrico Attanasio, Roberto Nagy, Endre V. Hegedüs, Laszlo Front Endocrinol (Lausanne) Endocrinology BACKGROUND: The standard treatment of hypothyroidism is levothyroxine (LT-4). However, there are several controversies regarding treatment of hypothyroid patients. AIM: To investigate the Swedish endocrinologists’ use of thyroid hormones in hypothyroid and euthyroid individuals. METHODS: Physician members of the Swedish Endocrine Society (SEF) were invited by e-mail to participate in an online survey investigating this topic. RESULTS: Out of the eligible 411 members, 116 (28.2%) responded. The majority (98.9%) stated that L-T4 is the treatment of choice. However, around 50% also prescribed liothyronine (L-T3) or a combination of L-T4+L-T3 in their practice. Combination therapy was mostly (78.5%) used in patients with persistent hypothyroid symptoms despite biochemical euthyroidism on L-T4 treatment. Most respondents prescribed L-T4 tablets and did not expect any major changes with alternative formulations such as soft-gel capsules or liquid formulations in situations influencing the bioavailability of L-T4. In euthyroid patients, 49.5% replied that treatment with thyroid hormones was never indicated, while 47.3% would consider L-T4 for euthyroid infertile women with high thyroid peroxidase (TPO) antibody levels. CONCLUSION: The treatment of choice for hypothyroidism in Sweden is L-T4 tablets. Combination therapy with L-T4+L-T3 tablets was considered for patients with persistent symptoms despite biochemical euthyroidism. Soft-gel capsules and liquid solutions of L-T4 were infrequently prescribed. Swedish endocrinologists’ deviation from endocrine society guidelines merits further study. Frontiers Media S.A. 2021-12-06 /pmc/articles/PMC8687360/ /pubmed/34938274 http://dx.doi.org/10.3389/fendo.2021.795111 Text en Copyright © 2021 Planck, Lantz, Perros, Papini, Attanasio, Nagy and Hegedüs https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Planck, Tereza
Lantz, Mikael
Perros, Petros
Papini, Enrico
Attanasio, Roberto
Nagy, Endre V.
Hegedüs, Laszlo
Use of Thyroid Hormones in Hypothyroid and Euthyroid Patients: A 2020 THESIS Questionnaire Survey of Members of the Swedish Endocrine Society
title Use of Thyroid Hormones in Hypothyroid and Euthyroid Patients: A 2020 THESIS Questionnaire Survey of Members of the Swedish Endocrine Society
title_full Use of Thyroid Hormones in Hypothyroid and Euthyroid Patients: A 2020 THESIS Questionnaire Survey of Members of the Swedish Endocrine Society
title_fullStr Use of Thyroid Hormones in Hypothyroid and Euthyroid Patients: A 2020 THESIS Questionnaire Survey of Members of the Swedish Endocrine Society
title_full_unstemmed Use of Thyroid Hormones in Hypothyroid and Euthyroid Patients: A 2020 THESIS Questionnaire Survey of Members of the Swedish Endocrine Society
title_short Use of Thyroid Hormones in Hypothyroid and Euthyroid Patients: A 2020 THESIS Questionnaire Survey of Members of the Swedish Endocrine Society
title_sort use of thyroid hormones in hypothyroid and euthyroid patients: a 2020 thesis questionnaire survey of members of the swedish endocrine society
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687360/
https://www.ncbi.nlm.nih.gov/pubmed/34938274
http://dx.doi.org/10.3389/fendo.2021.795111
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