SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling

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Severe COVID-19 is associated with epithelial and endothelial barrier dysfunction within the lung as well as in distal organs. While it is appreciated that an exaggerated inflammatory response is associated with barrier dysfunction, the triggers of this pathology are unclear. Here, we report that ce...

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Detalles Bibliográficos
Autores principales: Biering, Scott B., de Sousa, Francielle Tramontini Gomes, Tjang, Laurentia V., Pahmeier, Felix, Ruan, Richard, Blanc, Sophie F., Patel, Trishna S., Worthington, Caroline M., Glasner, Dustin R., Castillo-Rojas, Bryan, Servellita, Venice, Lo, Nicholas T.N., Wong, Marcus P., Warnes, Colin M., Sandoval, Daniel R., Clausen, Thomas Mandel, Santos, Yale A., Ortega, Victoria, Aguilar, Hector C., Esko, Jeffrey D., Chui, Charles Y., Pak, John E., Beatty, P. Robert, Harris, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687463/
https://www.ncbi.nlm.nih.gov/pubmed/34931188
http://dx.doi.org/10.1101/2021.12.10.472112
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