Booster of mRNA-1273 Strengthens SARS-CoV-2 Omicron Neutralization

The Omicron variant of SARS-CoV-2 is raising concerns because of its increased transmissibility and potential for reduced susceptibility to antibody neutralization. To assess the potential risk of this variant to existing vaccines, serum samples from mRNA-1273 vaccine recipients were tested for neut...

Descripción completa

Detalles Bibliográficos
Autores principales: Doria-Rose, Nicole A., Shen, Xiaoying, Schmidt, Stephen D, O’Dell, Sijy, McDanal, Charlene, Feng, Wenhong, Tong, Jin, Eaton, Amanda, Maglinao, Maha, Tang, Haili, Manning, Kelly E., Edara, Venkata-Viswanadh, Lai, Lilin, Ellis, Madison, Moore, Kathryn, Floyd, Katharine, Foster, Stephanie L., Atmar, Robert L., Lyke, Kirsten E., Zhou, Tongqing, Wang, Lingshu, Zhang, Yi, Gaudinski, Martin R, Black, Walker P, Gordon, Ingelise, Guech, Mercy, Ledgerwood, Julie E, Misasi, John N, Widge, Alicia, Roberts, Paul C., Beigel, John, Korber, Bette, Pajon, Rolando, Mascola, John R., Suthar, Mehul S., Montefiori, David C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687471/
https://www.ncbi.nlm.nih.gov/pubmed/34931200
http://dx.doi.org/10.1101/2021.12.15.21267805
Descripción
Sumario:The Omicron variant of SARS-CoV-2 is raising concerns because of its increased transmissibility and potential for reduced susceptibility to antibody neutralization. To assess the potential risk of this variant to existing vaccines, serum samples from mRNA-1273 vaccine recipients were tested for neutralizing activity against Omicron and compared to neutralization titers against D614G and Beta in live virus and pseudovirus assays. Omicron was 41–84-fold less sensitive to neutralization than D614G and 5.3–7.4-fold less sensitive than Beta when assayed with serum samples obtained 4 weeks after 2 standard inoculations with 100 μg mRNA-1273. A 50 μg boost increased Omicron neutralization titers and may substantially reduce the risk of symptomatic vaccine breakthrough infections.

Ejemplares similares