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Booster of mRNA-1273 Strengthens SARS-CoV-2 Omicron Neutralization
The Omicron variant of SARS-CoV-2 is raising concerns because of its increased transmissibility and potential for reduced susceptibility to antibody neutralization. To assess the potential risk of this variant to existing vaccines, serum samples from mRNA-1273 vaccine recipients were tested for neut...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687471/ https://www.ncbi.nlm.nih.gov/pubmed/34931200 http://dx.doi.org/10.1101/2021.12.15.21267805 |
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| author | Doria-Rose, Nicole A. Shen, Xiaoying Schmidt, Stephen D O’Dell, Sijy McDanal, Charlene Feng, Wenhong Tong, Jin Eaton, Amanda Maglinao, Maha Tang, Haili Manning, Kelly E. Edara, Venkata-Viswanadh Lai, Lilin Ellis, Madison Moore, Kathryn Floyd, Katharine Foster, Stephanie L. Atmar, Robert L. Lyke, Kirsten E. Zhou, Tongqing Wang, Lingshu Zhang, Yi Gaudinski, Martin R Black, Walker P Gordon, Ingelise Guech, Mercy Ledgerwood, Julie E Misasi, John N Widge, Alicia Roberts, Paul C. Beigel, John Korber, Bette Pajon, Rolando Mascola, John R. Suthar, Mehul S. Montefiori, David C. |
| author_facet | Doria-Rose, Nicole A. Shen, Xiaoying Schmidt, Stephen D O’Dell, Sijy McDanal, Charlene Feng, Wenhong Tong, Jin Eaton, Amanda Maglinao, Maha Tang, Haili Manning, Kelly E. Edara, Venkata-Viswanadh Lai, Lilin Ellis, Madison Moore, Kathryn Floyd, Katharine Foster, Stephanie L. Atmar, Robert L. Lyke, Kirsten E. Zhou, Tongqing Wang, Lingshu Zhang, Yi Gaudinski, Martin R Black, Walker P Gordon, Ingelise Guech, Mercy Ledgerwood, Julie E Misasi, John N Widge, Alicia Roberts, Paul C. Beigel, John Korber, Bette Pajon, Rolando Mascola, John R. Suthar, Mehul S. Montefiori, David C. |
| author_sort | Doria-Rose, Nicole A. |
| collection | PubMed |
| description | The Omicron variant of SARS-CoV-2 is raising concerns because of its increased transmissibility and potential for reduced susceptibility to antibody neutralization. To assess the potential risk of this variant to existing vaccines, serum samples from mRNA-1273 vaccine recipients were tested for neutralizing activity against Omicron and compared to neutralization titers against D614G and Beta in live virus and pseudovirus assays. Omicron was 41–84-fold less sensitive to neutralization than D614G and 5.3–7.4-fold less sensitive than Beta when assayed with serum samples obtained 4 weeks after 2 standard inoculations with 100 μg mRNA-1273. A 50 μg boost increased Omicron neutralization titers and may substantially reduce the risk of symptomatic vaccine breakthrough infections. |
| format | Online Article Text |
| id | pubmed-8687471 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Cold Spring Harbor Laboratory |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-86874712021-12-21 Booster of mRNA-1273 Strengthens SARS-CoV-2 Omicron Neutralization Doria-Rose, Nicole A. Shen, Xiaoying Schmidt, Stephen D O’Dell, Sijy McDanal, Charlene Feng, Wenhong Tong, Jin Eaton, Amanda Maglinao, Maha Tang, Haili Manning, Kelly E. Edara, Venkata-Viswanadh Lai, Lilin Ellis, Madison Moore, Kathryn Floyd, Katharine Foster, Stephanie L. Atmar, Robert L. Lyke, Kirsten E. Zhou, Tongqing Wang, Lingshu Zhang, Yi Gaudinski, Martin R Black, Walker P Gordon, Ingelise Guech, Mercy Ledgerwood, Julie E Misasi, John N Widge, Alicia Roberts, Paul C. Beigel, John Korber, Bette Pajon, Rolando Mascola, John R. Suthar, Mehul S. Montefiori, David C. medRxiv Article The Omicron variant of SARS-CoV-2 is raising concerns because of its increased transmissibility and potential for reduced susceptibility to antibody neutralization. To assess the potential risk of this variant to existing vaccines, serum samples from mRNA-1273 vaccine recipients were tested for neutralizing activity against Omicron and compared to neutralization titers against D614G and Beta in live virus and pseudovirus assays. Omicron was 41–84-fold less sensitive to neutralization than D614G and 5.3–7.4-fold less sensitive than Beta when assayed with serum samples obtained 4 weeks after 2 standard inoculations with 100 μg mRNA-1273. A 50 μg boost increased Omicron neutralization titers and may substantially reduce the risk of symptomatic vaccine breakthrough infections. Cold Spring Harbor Laboratory 2021-12-20 /pmc/articles/PMC8687471/ /pubmed/34931200 http://dx.doi.org/10.1101/2021.12.15.21267805 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator. |
| spellingShingle | Article Doria-Rose, Nicole A. Shen, Xiaoying Schmidt, Stephen D O’Dell, Sijy McDanal, Charlene Feng, Wenhong Tong, Jin Eaton, Amanda Maglinao, Maha Tang, Haili Manning, Kelly E. Edara, Venkata-Viswanadh Lai, Lilin Ellis, Madison Moore, Kathryn Floyd, Katharine Foster, Stephanie L. Atmar, Robert L. Lyke, Kirsten E. Zhou, Tongqing Wang, Lingshu Zhang, Yi Gaudinski, Martin R Black, Walker P Gordon, Ingelise Guech, Mercy Ledgerwood, Julie E Misasi, John N Widge, Alicia Roberts, Paul C. Beigel, John Korber, Bette Pajon, Rolando Mascola, John R. Suthar, Mehul S. Montefiori, David C. Booster of mRNA-1273 Strengthens SARS-CoV-2 Omicron Neutralization |
| title | Booster of mRNA-1273 Strengthens SARS-CoV-2 Omicron Neutralization |
| title_full | Booster of mRNA-1273 Strengthens SARS-CoV-2 Omicron Neutralization |
| title_fullStr | Booster of mRNA-1273 Strengthens SARS-CoV-2 Omicron Neutralization |
| title_full_unstemmed | Booster of mRNA-1273 Strengthens SARS-CoV-2 Omicron Neutralization |
| title_short | Booster of mRNA-1273 Strengthens SARS-CoV-2 Omicron Neutralization |
| title_sort | booster of mrna-1273 strengthens sars-cov-2 omicron neutralization |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687471/ https://www.ncbi.nlm.nih.gov/pubmed/34931200 http://dx.doi.org/10.1101/2021.12.15.21267805 |
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