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FaDA: A web application for regular laboratory data analyses

Web-based data analysis and visualization tools are mostly designed for specific purposes, such as the analysis of data from whole transcriptome RNA sequencing or single-cell RNA sequencing. However, generic tools designed for the analysis of common laboratory data for noncomputational scientists ar...

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Detalles Bibliográficos
Autores principales: Danger, Richard, Moiteaux, Quentin, Feseha, Yodit, Geffard, Estelle, Ramstein, Gérard, Brouard, Sophie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687579/
https://www.ncbi.nlm.nih.gov/pubmed/34928943
http://dx.doi.org/10.1371/journal.pone.0261083
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author Danger, Richard
Moiteaux, Quentin
Feseha, Yodit
Geffard, Estelle
Ramstein, Gérard
Brouard, Sophie
author_facet Danger, Richard
Moiteaux, Quentin
Feseha, Yodit
Geffard, Estelle
Ramstein, Gérard
Brouard, Sophie
author_sort Danger, Richard
collection PubMed
description Web-based data analysis and visualization tools are mostly designed for specific purposes, such as the analysis of data from whole transcriptome RNA sequencing or single-cell RNA sequencing. However, generic tools designed for the analysis of common laboratory data for noncomputational scientists are also needed. The importance of such web-based tools is emphasized by the continuing increases in the sample capacity of conventional laboratory tools such as quantitative PCR, flow cytometry or ELISA instruments. We present a web-based application FaDA, developed with the R Shiny package that provides users with the ability to perform statistical group comparisons, including parametric and nonparametric tests, with multiple testing corrections suitable for most standard wet-laboratory analyses. FaDA provides data visualizations such as heatmaps, principal component analysis (PCA) plots, correlograms and receiver operating curves (ROCs). Calculations are performed through the R language. The FaDA application provides a free and intuitive interface that allows biologists without bioinformatic skill to easily and quickly perform common laboratory data analyses. The application is freely accessible at https://shiny-bird.univ-nantes.fr/app/Fada.
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spelling pubmed-86875792021-12-21 FaDA: A web application for regular laboratory data analyses Danger, Richard Moiteaux, Quentin Feseha, Yodit Geffard, Estelle Ramstein, Gérard Brouard, Sophie PLoS One Research Article Web-based data analysis and visualization tools are mostly designed for specific purposes, such as the analysis of data from whole transcriptome RNA sequencing or single-cell RNA sequencing. However, generic tools designed for the analysis of common laboratory data for noncomputational scientists are also needed. The importance of such web-based tools is emphasized by the continuing increases in the sample capacity of conventional laboratory tools such as quantitative PCR, flow cytometry or ELISA instruments. We present a web-based application FaDA, developed with the R Shiny package that provides users with the ability to perform statistical group comparisons, including parametric and nonparametric tests, with multiple testing corrections suitable for most standard wet-laboratory analyses. FaDA provides data visualizations such as heatmaps, principal component analysis (PCA) plots, correlograms and receiver operating curves (ROCs). Calculations are performed through the R language. The FaDA application provides a free and intuitive interface that allows biologists without bioinformatic skill to easily and quickly perform common laboratory data analyses. The application is freely accessible at https://shiny-bird.univ-nantes.fr/app/Fada. Public Library of Science 2021-12-20 /pmc/articles/PMC8687579/ /pubmed/34928943 http://dx.doi.org/10.1371/journal.pone.0261083 Text en © 2021 Danger et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Danger, Richard
Moiteaux, Quentin
Feseha, Yodit
Geffard, Estelle
Ramstein, Gérard
Brouard, Sophie
FaDA: A web application for regular laboratory data analyses
title FaDA: A web application for regular laboratory data analyses
title_full FaDA: A web application for regular laboratory data analyses
title_fullStr FaDA: A web application for regular laboratory data analyses
title_full_unstemmed FaDA: A web application for regular laboratory data analyses
title_short FaDA: A web application for regular laboratory data analyses
title_sort fada: a web application for regular laboratory data analyses
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687579/
https://www.ncbi.nlm.nih.gov/pubmed/34928943
http://dx.doi.org/10.1371/journal.pone.0261083
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