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Characterization of the adaptive immune response of donors receiving live anthrax vaccine

Live anthrax vaccine containing spores from attenuated strains STI-1 of Bacillus anthracis is used in Russia and former CIS (Commonwealth of Independent States) to prevent anthrax. In this paper we studied the duration of circulation of antibodies specific to spore antigens, the protective antigen (...

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Autores principales: Firstova, Victoria V., Shakhova, Anastasia S., Riabko, Alena K., Silkina, Marina V., Zeninskaya, Natalia A., Romanenko, Yana O., Marin, Maksim A., Rogozin, Methun M., Kartseva, Alena S., Dyatlov, Ivan A., Shemyakin, Igor G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687594/
https://www.ncbi.nlm.nih.gov/pubmed/34928976
http://dx.doi.org/10.1371/journal.pone.0260202
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author Firstova, Victoria V.
Shakhova, Anastasia S.
Riabko, Alena K.
Silkina, Marina V.
Zeninskaya, Natalia A.
Romanenko, Yana O.
Marin, Maksim A.
Rogozin, Methun M.
Kartseva, Alena S.
Dyatlov, Ivan A.
Shemyakin, Igor G.
author_facet Firstova, Victoria V.
Shakhova, Anastasia S.
Riabko, Alena K.
Silkina, Marina V.
Zeninskaya, Natalia A.
Romanenko, Yana O.
Marin, Maksim A.
Rogozin, Methun M.
Kartseva, Alena S.
Dyatlov, Ivan A.
Shemyakin, Igor G.
author_sort Firstova, Victoria V.
collection PubMed
description Live anthrax vaccine containing spores from attenuated strains STI-1 of Bacillus anthracis is used in Russia and former CIS (Commonwealth of Independent States) to prevent anthrax. In this paper we studied the duration of circulation of antibodies specific to spore antigens, the protective antigen (PA), the lethal factor (LF) and their domains (D) in donors’ blood at different times after their immunization with live anthrax vaccine. The relationship between the toxin neutralization activity level and the level of antibodies to PA, LF and their domains was tested. The effect of age, gender and number of vaccinations on the level of adaptive post-vaccination immune response has been studied. It was shown that antibodies against PA-D1 circulate in the blood of donors for 1 year or more after immunization with live anthrax vaccine. Antibodies against all domains of LF and PA-D4 were detected in 11 months after vaccination. Antibodies against the spores were detected in 8 months after vaccination. A moderate positive correlation was found between the titers of antibodies to PA, LF, or their domains, and the TNA of the samples of blood serum from the donors.
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spelling pubmed-86875942021-12-21 Characterization of the adaptive immune response of donors receiving live anthrax vaccine Firstova, Victoria V. Shakhova, Anastasia S. Riabko, Alena K. Silkina, Marina V. Zeninskaya, Natalia A. Romanenko, Yana O. Marin, Maksim A. Rogozin, Methun M. Kartseva, Alena S. Dyatlov, Ivan A. Shemyakin, Igor G. PLoS One Research Article Live anthrax vaccine containing spores from attenuated strains STI-1 of Bacillus anthracis is used in Russia and former CIS (Commonwealth of Independent States) to prevent anthrax. In this paper we studied the duration of circulation of antibodies specific to spore antigens, the protective antigen (PA), the lethal factor (LF) and their domains (D) in donors’ blood at different times after their immunization with live anthrax vaccine. The relationship between the toxin neutralization activity level and the level of antibodies to PA, LF and their domains was tested. The effect of age, gender and number of vaccinations on the level of adaptive post-vaccination immune response has been studied. It was shown that antibodies against PA-D1 circulate in the blood of donors for 1 year or more after immunization with live anthrax vaccine. Antibodies against all domains of LF and PA-D4 were detected in 11 months after vaccination. Antibodies against the spores were detected in 8 months after vaccination. A moderate positive correlation was found between the titers of antibodies to PA, LF, or their domains, and the TNA of the samples of blood serum from the donors. Public Library of Science 2021-12-20 /pmc/articles/PMC8687594/ /pubmed/34928976 http://dx.doi.org/10.1371/journal.pone.0260202 Text en © 2021 Firstova et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Firstova, Victoria V.
Shakhova, Anastasia S.
Riabko, Alena K.
Silkina, Marina V.
Zeninskaya, Natalia A.
Romanenko, Yana O.
Marin, Maksim A.
Rogozin, Methun M.
Kartseva, Alena S.
Dyatlov, Ivan A.
Shemyakin, Igor G.
Characterization of the adaptive immune response of donors receiving live anthrax vaccine
title Characterization of the adaptive immune response of donors receiving live anthrax vaccine
title_full Characterization of the adaptive immune response of donors receiving live anthrax vaccine
title_fullStr Characterization of the adaptive immune response of donors receiving live anthrax vaccine
title_full_unstemmed Characterization of the adaptive immune response of donors receiving live anthrax vaccine
title_short Characterization of the adaptive immune response of donors receiving live anthrax vaccine
title_sort characterization of the adaptive immune response of donors receiving live anthrax vaccine
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687594/
https://www.ncbi.nlm.nih.gov/pubmed/34928976
http://dx.doi.org/10.1371/journal.pone.0260202
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