Extracellular Matrix in Heart Failure: Role of ADAMTS5 in Proteoglycan Remodeling

Remodeling of the extracellular matrix (ECM) is a hallmark of heart failure (HF). Our previous analysis of the secretome of murine cardiac fibroblasts returned ADAMTS5 (a disintegrin and metalloproteinase with thrombospondin motifs 5) as one of the most abundant proteases. ADAMTS5 cleaves chondroiti...

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Detalles Bibliográficos
Autores principales: Barallobre-Barreiro, Javier, Radovits, Tamás, Fava, Marika, Mayr, Ursula, Lin, Wen-Yu, Ermolaeva, Elizaveta, Martínez-López, Diego, Lindberg, Eric L., Duregotti, Elisa, Daróczi, László, Hasman, Maria, Schmidt, Lukas E., Singh, Bhawana, Lu, Ruifang, Baig, Ferheen, Siedlar, Aleksandra Malgorzata, Cuello, Friederike, Catibog, Norman, Theofilatos, Konstantinos, Shah, Ajay M., Crespo-Leiro, Maria G., Doménech, Nieves, Hübner, Norbert, Merkely, Béla, Mayr, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Original Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687617/
https://www.ncbi.nlm.nih.gov/pubmed/34806902
http://dx.doi.org/10.1161/CIRCULATIONAHA.121.055732

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