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Response kinetics of different classes of antibodies to SARS-CoV2 infection in the Japanese population: The IgA and IgG titers increased earlier than the IgM titers
To better understand the immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in individuals with COVID-19, it is important to investigate the kinetics of the antibody responses and their associations with the clinical course in different populations, since ther...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Authors. Published by Elsevier B.V.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687758/ https://www.ncbi.nlm.nih.gov/pubmed/34954559 http://dx.doi.org/10.1016/j.intimp.2021.108491 |
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author | Kurano, Makoto Morita, Yoshifumi Nakano, Yuki Yokoyama, Rin Shimura, Takuya Qian, Chungen Xia, Fuzhen He, Fan Zheng, Liang Ohmiya, Hiroko Kishi, Yoshiro Okada, Jun Yoshikawa, Naoyuki Nakajima, Kazuki Nagura, Yutaka Okazaki, Hitoshi Jubishi, Daisuke Moriya, Kyoji Seto, Yasuyuki Yasui, Fumihiko Kohara, Michinori Wakui, Masatoshi Kawamura, Takeshi Kodama, Tatsuhiko Yatomi, Yutaka |
author_facet | Kurano, Makoto Morita, Yoshifumi Nakano, Yuki Yokoyama, Rin Shimura, Takuya Qian, Chungen Xia, Fuzhen He, Fan Zheng, Liang Ohmiya, Hiroko Kishi, Yoshiro Okada, Jun Yoshikawa, Naoyuki Nakajima, Kazuki Nagura, Yutaka Okazaki, Hitoshi Jubishi, Daisuke Moriya, Kyoji Seto, Yasuyuki Yasui, Fumihiko Kohara, Michinori Wakui, Masatoshi Kawamura, Takeshi Kodama, Tatsuhiko Yatomi, Yutaka |
author_sort | Kurano, Makoto |
collection | PubMed |
description | To better understand the immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in individuals with COVID-19, it is important to investigate the kinetics of the antibody responses and their associations with the clinical course in different populations, since there seem to be considerable differences between Western and Asian populations in the clinical features and spread of COVID-19. In this study, we serially measured the serum titers of IgM, IgG and IgA antibodies generated against the nucleocapsid protein (NCP), S1 subunit of the spike protein (S1), and receptor-binding domain in the S1 subunit (RBD) of SARS-CoV-2 in Japanese individuals with COVID-19. Among the IgM, IgG, and IgA antibodies, IgA antibodies against all of the aforementioned viral proteins were the first to appear after the infection, and IgG and/or IgA seroconversion often preceded IgM seroconversion. In regard to the timeline of the antibody responses to the different viral proteins (NCP, S1 and RBD), IgA against NCP appeared than IgA against S1 or RBD, while IgM and IgG against S1 appeared earlier than IgM/IgG against NCP or RBD. The IgG responses to all three viral proteins and responses of all three antibody classes to S1 and RBD were sustained for longer durations than the IgA/IgM responses to all three viral proteins and responses of all three antibody classes to NCP, respectively. The seroconversion of IgA against NCP occurred later and less frequently in patients with mild COVID-19. These results suggest possible differences in the antibody responses to SARS-CoV-2 antigens between the Japanese and Western populations. |
format | Online Article Text |
id | pubmed-8687758 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Authors. Published by Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86877582021-12-21 Response kinetics of different classes of antibodies to SARS-CoV2 infection in the Japanese population: The IgA and IgG titers increased earlier than the IgM titers Kurano, Makoto Morita, Yoshifumi Nakano, Yuki Yokoyama, Rin Shimura, Takuya Qian, Chungen Xia, Fuzhen He, Fan Zheng, Liang Ohmiya, Hiroko Kishi, Yoshiro Okada, Jun Yoshikawa, Naoyuki Nakajima, Kazuki Nagura, Yutaka Okazaki, Hitoshi Jubishi, Daisuke Moriya, Kyoji Seto, Yasuyuki Yasui, Fumihiko Kohara, Michinori Wakui, Masatoshi Kawamura, Takeshi Kodama, Tatsuhiko Yatomi, Yutaka Int Immunopharmacol Article To better understand the immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in individuals with COVID-19, it is important to investigate the kinetics of the antibody responses and their associations with the clinical course in different populations, since there seem to be considerable differences between Western and Asian populations in the clinical features and spread of COVID-19. In this study, we serially measured the serum titers of IgM, IgG and IgA antibodies generated against the nucleocapsid protein (NCP), S1 subunit of the spike protein (S1), and receptor-binding domain in the S1 subunit (RBD) of SARS-CoV-2 in Japanese individuals with COVID-19. Among the IgM, IgG, and IgA antibodies, IgA antibodies against all of the aforementioned viral proteins were the first to appear after the infection, and IgG and/or IgA seroconversion often preceded IgM seroconversion. In regard to the timeline of the antibody responses to the different viral proteins (NCP, S1 and RBD), IgA against NCP appeared than IgA against S1 or RBD, while IgM and IgG against S1 appeared earlier than IgM/IgG against NCP or RBD. The IgG responses to all three viral proteins and responses of all three antibody classes to S1 and RBD were sustained for longer durations than the IgA/IgM responses to all three viral proteins and responses of all three antibody classes to NCP, respectively. The seroconversion of IgA against NCP occurred later and less frequently in patients with mild COVID-19. These results suggest possible differences in the antibody responses to SARS-CoV-2 antigens between the Japanese and Western populations. The Authors. Published by Elsevier B.V. 2022-02 2021-12-21 /pmc/articles/PMC8687758/ /pubmed/34954559 http://dx.doi.org/10.1016/j.intimp.2021.108491 Text en © 2021 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Kurano, Makoto Morita, Yoshifumi Nakano, Yuki Yokoyama, Rin Shimura, Takuya Qian, Chungen Xia, Fuzhen He, Fan Zheng, Liang Ohmiya, Hiroko Kishi, Yoshiro Okada, Jun Yoshikawa, Naoyuki Nakajima, Kazuki Nagura, Yutaka Okazaki, Hitoshi Jubishi, Daisuke Moriya, Kyoji Seto, Yasuyuki Yasui, Fumihiko Kohara, Michinori Wakui, Masatoshi Kawamura, Takeshi Kodama, Tatsuhiko Yatomi, Yutaka Response kinetics of different classes of antibodies to SARS-CoV2 infection in the Japanese population: The IgA and IgG titers increased earlier than the IgM titers |
title | Response kinetics of different classes of antibodies to SARS-CoV2 infection in the Japanese population: The IgA and IgG titers increased earlier than the IgM titers |
title_full | Response kinetics of different classes of antibodies to SARS-CoV2 infection in the Japanese population: The IgA and IgG titers increased earlier than the IgM titers |
title_fullStr | Response kinetics of different classes of antibodies to SARS-CoV2 infection in the Japanese population: The IgA and IgG titers increased earlier than the IgM titers |
title_full_unstemmed | Response kinetics of different classes of antibodies to SARS-CoV2 infection in the Japanese population: The IgA and IgG titers increased earlier than the IgM titers |
title_short | Response kinetics of different classes of antibodies to SARS-CoV2 infection in the Japanese population: The IgA and IgG titers increased earlier than the IgM titers |
title_sort | response kinetics of different classes of antibodies to sars-cov2 infection in the japanese population: the iga and igg titers increased earlier than the igm titers |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687758/ https://www.ncbi.nlm.nih.gov/pubmed/34954559 http://dx.doi.org/10.1016/j.intimp.2021.108491 |
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