Cargando…

Pharmacological Actions, Molecular Mechanisms, Pharmacokinetic Progressions, and Clinical Applications of Hydroxysafflor Yellow A in Antidiabetic Research

Hydroxysafflor yellow A (HSYA), a nutraceutical compound derived from safflower (Carthamus tinctorius), has been shown as an effective therapeutic agent in cardiovascular diseases, cancer, and diabetes. Our previous study showed that the effect of HSYA on high-glucose-induced podocyte injury is rela...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Xilan, Shen, Dayue, Feng, Yating, Li, Yuanping, Liao, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687819/
https://www.ncbi.nlm.nih.gov/pubmed/34938814
http://dx.doi.org/10.1155/2021/4560012
_version_ 1784618253569490944
author Zhang, Xilan
Shen, Dayue
Feng, Yating
Li, Yuanping
Liao, Hui
author_facet Zhang, Xilan
Shen, Dayue
Feng, Yating
Li, Yuanping
Liao, Hui
author_sort Zhang, Xilan
collection PubMed
description Hydroxysafflor yellow A (HSYA), a nutraceutical compound derived from safflower (Carthamus tinctorius), has been shown as an effective therapeutic agent in cardiovascular diseases, cancer, and diabetes. Our previous study showed that the effect of HSYA on high-glucose-induced podocyte injury is related to its anti-inflammatory activities via macrophage polarization. Based on the information provided on PubMed, Scopus and Wanfang database, we currently aim to provide an updated overview of the role of HSYA in antidiabetic research from the following points: pharmacological actions, molecular mechanisms, pharmacokinetic progressions, and clinical applications. The pharmacokinetic research of HSYA has laid foundations for the clinical applications of HSYA injection in diabetic nephropathy, diabetic retinopathy, and diabetic neuropathy. The application of HSYA as an antidiabetic oral medicament has been investigated based on its recent oral delivery system research. In vivo and in vitro pharmacological research indicated that the antidiabetic activities of HSYA were based mainly on its antioxidant and anti-inflammatory mechanisms via JNK/c-jun pathway, NOX4 pathway, and macrophage differentiation. Further anti-inflammatory exploration related to NF-κB signaling, MAPK pathway, and PI3K/Akt/mTOR pathway might deserve attention in the future. The anti-inflammatory activities of HSYA related to diabetes and diabetic complications will be a highlight in our following research.
format Online
Article
Text
id pubmed-8687819
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-86878192021-12-21 Pharmacological Actions, Molecular Mechanisms, Pharmacokinetic Progressions, and Clinical Applications of Hydroxysafflor Yellow A in Antidiabetic Research Zhang, Xilan Shen, Dayue Feng, Yating Li, Yuanping Liao, Hui J Immunol Res Review Article Hydroxysafflor yellow A (HSYA), a nutraceutical compound derived from safflower (Carthamus tinctorius), has been shown as an effective therapeutic agent in cardiovascular diseases, cancer, and diabetes. Our previous study showed that the effect of HSYA on high-glucose-induced podocyte injury is related to its anti-inflammatory activities via macrophage polarization. Based on the information provided on PubMed, Scopus and Wanfang database, we currently aim to provide an updated overview of the role of HSYA in antidiabetic research from the following points: pharmacological actions, molecular mechanisms, pharmacokinetic progressions, and clinical applications. The pharmacokinetic research of HSYA has laid foundations for the clinical applications of HSYA injection in diabetic nephropathy, diabetic retinopathy, and diabetic neuropathy. The application of HSYA as an antidiabetic oral medicament has been investigated based on its recent oral delivery system research. In vivo and in vitro pharmacological research indicated that the antidiabetic activities of HSYA were based mainly on its antioxidant and anti-inflammatory mechanisms via JNK/c-jun pathway, NOX4 pathway, and macrophage differentiation. Further anti-inflammatory exploration related to NF-κB signaling, MAPK pathway, and PI3K/Akt/mTOR pathway might deserve attention in the future. The anti-inflammatory activities of HSYA related to diabetes and diabetic complications will be a highlight in our following research. Hindawi 2021-12-13 /pmc/articles/PMC8687819/ /pubmed/34938814 http://dx.doi.org/10.1155/2021/4560012 Text en Copyright © 2021 Xilan Zhang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Zhang, Xilan
Shen, Dayue
Feng, Yating
Li, Yuanping
Liao, Hui
Pharmacological Actions, Molecular Mechanisms, Pharmacokinetic Progressions, and Clinical Applications of Hydroxysafflor Yellow A in Antidiabetic Research
title Pharmacological Actions, Molecular Mechanisms, Pharmacokinetic Progressions, and Clinical Applications of Hydroxysafflor Yellow A in Antidiabetic Research
title_full Pharmacological Actions, Molecular Mechanisms, Pharmacokinetic Progressions, and Clinical Applications of Hydroxysafflor Yellow A in Antidiabetic Research
title_fullStr Pharmacological Actions, Molecular Mechanisms, Pharmacokinetic Progressions, and Clinical Applications of Hydroxysafflor Yellow A in Antidiabetic Research
title_full_unstemmed Pharmacological Actions, Molecular Mechanisms, Pharmacokinetic Progressions, and Clinical Applications of Hydroxysafflor Yellow A in Antidiabetic Research
title_short Pharmacological Actions, Molecular Mechanisms, Pharmacokinetic Progressions, and Clinical Applications of Hydroxysafflor Yellow A in Antidiabetic Research
title_sort pharmacological actions, molecular mechanisms, pharmacokinetic progressions, and clinical applications of hydroxysafflor yellow a in antidiabetic research
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8687819/
https://www.ncbi.nlm.nih.gov/pubmed/34938814
http://dx.doi.org/10.1155/2021/4560012
work_keys_str_mv AT zhangxilan pharmacologicalactionsmolecularmechanismspharmacokineticprogressionsandclinicalapplicationsofhydroxysaffloryellowainantidiabeticresearch
AT shendayue pharmacologicalactionsmolecularmechanismspharmacokineticprogressionsandclinicalapplicationsofhydroxysaffloryellowainantidiabeticresearch
AT fengyating pharmacologicalactionsmolecularmechanismspharmacokineticprogressionsandclinicalapplicationsofhydroxysaffloryellowainantidiabeticresearch
AT liyuanping pharmacologicalactionsmolecularmechanismspharmacokineticprogressionsandclinicalapplicationsofhydroxysaffloryellowainantidiabeticresearch
AT liaohui pharmacologicalactionsmolecularmechanismspharmacokineticprogressionsandclinicalapplicationsofhydroxysaffloryellowainantidiabeticresearch