The mechanisms of action of ivermectin against SARS-CoV-2—an extensive review

Considering the urgency of the ongoing COVID-19 pandemic, detection of new mutant strains and potential re-emergence of novel coronaviruses, repurposing of drugs such as ivermectin could be worthy of attention. This review article aims to discuss the probable mechanisms of action of ivermectin again...

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Detalles Bibliográficos
Autores principales: Zaidi, Asiya Kamber, Dehgani-Mobaraki, Puya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688140/
https://www.ncbi.nlm.nih.gov/pubmed/34931048
http://dx.doi.org/10.1038/s41429-021-00491-6
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author Zaidi, Asiya Kamber
Dehgani-Mobaraki, Puya
author_facet Zaidi, Asiya Kamber
Dehgani-Mobaraki, Puya
author_sort Zaidi, Asiya Kamber
collection PubMed
description Considering the urgency of the ongoing COVID-19 pandemic, detection of new mutant strains and potential re-emergence of novel coronaviruses, repurposing of drugs such as ivermectin could be worthy of attention. This review article aims to discuss the probable mechanisms of action of ivermectin against SARS-CoV-2 by summarizing the available literature over the years. A schematic of the key cellular and biomolecular interactions between ivermectin, host cell, and SARS-CoV-2 in COVID-19 pathogenesis and prevention of complications has been proposed.
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spelling pubmed-86881402021-12-21 The mechanisms of action of ivermectin against SARS-CoV-2—an extensive review Zaidi, Asiya Kamber Dehgani-Mobaraki, Puya J Antibiot (Tokyo) Review Article Considering the urgency of the ongoing COVID-19 pandemic, detection of new mutant strains and potential re-emergence of novel coronaviruses, repurposing of drugs such as ivermectin could be worthy of attention. This review article aims to discuss the probable mechanisms of action of ivermectin against SARS-CoV-2 by summarizing the available literature over the years. A schematic of the key cellular and biomolecular interactions between ivermectin, host cell, and SARS-CoV-2 in COVID-19 pathogenesis and prevention of complications has been proposed. Nature Publishing Group UK 2021-12-21 2022 /pmc/articles/PMC8688140/ /pubmed/34931048 http://dx.doi.org/10.1038/s41429-021-00491-6 Text en © The Author(s), under exclusive licence to the Japan Antibiotics Research Association 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review Article
Zaidi, Asiya Kamber
Dehgani-Mobaraki, Puya
The mechanisms of action of ivermectin against SARS-CoV-2—an extensive review
title The mechanisms of action of ivermectin against SARS-CoV-2—an extensive review
title_full The mechanisms of action of ivermectin against SARS-CoV-2—an extensive review
title_fullStr The mechanisms of action of ivermectin against SARS-CoV-2—an extensive review
title_full_unstemmed The mechanisms of action of ivermectin against SARS-CoV-2—an extensive review
title_short The mechanisms of action of ivermectin against SARS-CoV-2—an extensive review
title_sort mechanisms of action of ivermectin against sars-cov-2—an extensive review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688140/
https://www.ncbi.nlm.nih.gov/pubmed/34931048
http://dx.doi.org/10.1038/s41429-021-00491-6
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