NADH inhibition of SIRT1 links energy state to transcription during time-restricted feeding

In mammals, circadian rhythms are entrained to the light cycle and drive daily oscillations in levels of NAD(+), a cosubstrate of the class III histone deacetylase sirtuin 1 (SIRT1) that associates with clock transcription factors. Although NAD(+) also participates in redox reactions, the extent to...

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Detalles Bibliográficos
Autores principales: Levine, Daniel C., Kuo, Hsin-Yu, Hong, Hee-Kyung, Cedernaes, Jonathan, Hepler, Chelsea, Wright, Alexandra G., Sommars, Meredith A., Kobayashi, Yumiko, Marcheva, Biliana, Gao, Peng, Ilkayeva, Olga R., Omura, Chiaki, Ramsey, Kathryn M., Newgard, Christopher B., Barish, Grant D., Peek, Clara Bien, Chandel, Navdeep S., Mrksich, Milan, Bass, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688143/
https://www.ncbi.nlm.nih.gov/pubmed/34903884
http://dx.doi.org/10.1038/s42255-021-00498-1

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