Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity

Insulin acts on neurons and glial cells to regulate systemic glucose metabolism and feeding. However, the mechanisms of insulin access in discrete brain regions are incompletely defined. Here we show that insulin receptors in tanycytes, but not in brain endothelial cells, are required to regulate in...

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Detalles Bibliográficos
Autores principales: Porniece Kumar, Marta, Cremer, Anna Lena, Klemm, Paul, Steuernagel, Lukas, Sundaram, Sivaraj, Jais, Alexander, Hausen, A. Christine, Tao, Jenkang, Secher, Anna, Pedersen, Thomas Åskov, Schwaninger, Markus, Wunderlich, F. Thomas, Lowell, Bradford B., Backes, Heiko, Brüning, Jens C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688146/
https://www.ncbi.nlm.nih.gov/pubmed/34931084
http://dx.doi.org/10.1038/s42255-021-00499-0

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