Tofacitinib-Induced Modulation of Intestinal Adaptive and Innate Immunity and Factors Driving Cellular and Systemic Pharmacokinetics

OBJECTIVE: By interfering with multiple cytokines, human Janus kinase inhibitors (JAKis) are of growing importance in the treatment of malignant and inflammatory conditions. Although tofacitinib has demonstrated efficacy as the first-in-class JAKi in ulcerative colitis many aspects concerning its mo...

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Detalles Bibliográficos
Autores principales: Texler, Bernhard, Zollner, Andreas, Reinstadler, Vera, Reider, Simon J., Macheiner, Sophie, Jelusic, Barbara, Pfister, Alexandra, Watschinger, Christina, Przysiecki, Nicole, Tilg, Herbert, Oberacher, Herbert, Moschen, Alexander R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688178/
https://www.ncbi.nlm.nih.gov/pubmed/34624526
http://dx.doi.org/10.1016/j.jcmgh.2021.09.004

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