A scalable, clinically severe pig model for Duchenne muscular dystrophy

Large-animal models for Duchenne muscular dystrophy (DMD) are crucial for the evaluation of diagnostic procedures and treatment strategies. Pigs cloned from male cells lacking DMD exon 52 (DMDΔ52) exhibit molecular, clinical and pathological hallmarks of DMD, but die before sexual maturity and canno...

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Detalles Bibliográficos
Autores principales: Stirm, Michael, Fonteyne, Lina Marie, Shashikadze, Bachuki, Lindner, Magdalena, Chirivi, Maila, Lange, Andreas, Kaufhold, Clara, Mayer, Christian, Medugorac, Ivica, Kessler, Barbara, Kurome, Mayuko, Zakhartchenko, Valeri, Hinrichs, Arne, Kemter, Elisabeth, Krause, Sabine, Wanke, Rüdiger, Arnold, Georg J., Wess, Gerhard, Nagashima, Hiroshi, Hrabĕ de Angelis, Martin, Flenkenthaler, Florian, Kobelke, Levin Arne, Bearzi, Claudia, Rizzi, Roberto, Bähr, Andrea, Reese, Sven, Matiasek, Kaspar, Walter, Maggie C., Kupatt, Christian, Ziegler, Sibylle, Bartenstein, Peter, Fröhlich, Thomas, Klymiuk, Nikolai, Blutke, Andreas, Wolf, Eckhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2021
Materias:
Resource Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688409/
https://www.ncbi.nlm.nih.gov/pubmed/34796900
http://dx.doi.org/10.1242/dmm.049285

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