Evidence of feedback regulation of C-type natriuretic peptide during Vosoritide therapy in Achondroplasia

Evidence from genetic disorders of CNP signalling suggests that plasma concentrations of CNP are subject to feedback regulation. In subjects with Achondroplasia (Ach), CNP intracellular activity is suppressed and plasma concentrations are raised but the therapeutic impact of exogenous CNP agonists o...

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Detalles Bibliográficos
Autores principales: Prickett, Timothy C. R., Espiner, Eric A., Irving, Melita, Bacino, Carlos, Phillips, John A., Savarirayan, Ravi, Day, Jonathan R. S., Fisheleva, Elena, Larimore, Kevin, Chan, Ming Liang, Jeha, George S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688426/
https://www.ncbi.nlm.nih.gov/pubmed/34930956
http://dx.doi.org/10.1038/s41598-021-03593-1

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