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Usefulness of arterial spin labeling perfusion as an initial evaluation of status epilepticus

This study aimed to evaluate the sensitivity and prognostic value of arterial spin labeling (ASL) in a large group of status epilepticus (SE) patients and compare them with those of other magnetic resonance (MR) sequences, including dynamic susceptibility contrast (DSC) perfusion imaging. We retrosp...

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Autores principales: Kim, Tae-Joon, Choi, Jin Wook, Han, Miran, Kim, Byung Gon, Park, Sun Ah, Huh, Kyoon, Choi, Jun Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688435/
https://www.ncbi.nlm.nih.gov/pubmed/34930959
http://dx.doi.org/10.1038/s41598-021-03698-7
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author Kim, Tae-Joon
Choi, Jin Wook
Han, Miran
Kim, Byung Gon
Park, Sun Ah
Huh, Kyoon
Choi, Jun Young
author_facet Kim, Tae-Joon
Choi, Jin Wook
Han, Miran
Kim, Byung Gon
Park, Sun Ah
Huh, Kyoon
Choi, Jun Young
author_sort Kim, Tae-Joon
collection PubMed
description This study aimed to evaluate the sensitivity and prognostic value of arterial spin labeling (ASL) in a large group of status epilepticus (SE) patients and compare them with those of other magnetic resonance (MR) sequences, including dynamic susceptibility contrast (DSC) perfusion imaging. We retrospectively collected data of patients with SE in a tertiary center between September 2016 and March 2020. MR images were visually assessed, and the sensitivity for the detection of SE and prognostication was compared among multi-delay ASL, DSC, fluid-attenuated inversion recovery (FLAIR), and diffusion-weighted imaging (DWI). We included 51 SE patients and 46 patients with self-limiting seizures for comparison. Relevant changes in ASL were observed in 90.2% (46/51) of SE patients, a percentage higher than those for DSC, FLAIR, and DWI. ASL was the most sensitive method for initial differentiation between SE and self-limiting seizures. The sensitivity of ASL for detecting refractory SE (89.5%) or estimating poor outcomes (100%) was higher than those of other MR protocols or electroencephalography and comparable to those of clinical prognostic scores, although the specificity of ASL was very low as 9.4% and 15.6%, respectively. ASL showed a better ability to detect SE and predict the prognosis than other MR sequences, therefore it can be valuable for the initial evaluation of patients with SE.
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spelling pubmed-86884352021-12-22 Usefulness of arterial spin labeling perfusion as an initial evaluation of status epilepticus Kim, Tae-Joon Choi, Jin Wook Han, Miran Kim, Byung Gon Park, Sun Ah Huh, Kyoon Choi, Jun Young Sci Rep Article This study aimed to evaluate the sensitivity and prognostic value of arterial spin labeling (ASL) in a large group of status epilepticus (SE) patients and compare them with those of other magnetic resonance (MR) sequences, including dynamic susceptibility contrast (DSC) perfusion imaging. We retrospectively collected data of patients with SE in a tertiary center between September 2016 and March 2020. MR images were visually assessed, and the sensitivity for the detection of SE and prognostication was compared among multi-delay ASL, DSC, fluid-attenuated inversion recovery (FLAIR), and diffusion-weighted imaging (DWI). We included 51 SE patients and 46 patients with self-limiting seizures for comparison. Relevant changes in ASL were observed in 90.2% (46/51) of SE patients, a percentage higher than those for DSC, FLAIR, and DWI. ASL was the most sensitive method for initial differentiation between SE and self-limiting seizures. The sensitivity of ASL for detecting refractory SE (89.5%) or estimating poor outcomes (100%) was higher than those of other MR protocols or electroencephalography and comparable to those of clinical prognostic scores, although the specificity of ASL was very low as 9.4% and 15.6%, respectively. ASL showed a better ability to detect SE and predict the prognosis than other MR sequences, therefore it can be valuable for the initial evaluation of patients with SE. Nature Publishing Group UK 2021-12-20 /pmc/articles/PMC8688435/ /pubmed/34930959 http://dx.doi.org/10.1038/s41598-021-03698-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Kim, Tae-Joon
Choi, Jin Wook
Han, Miran
Kim, Byung Gon
Park, Sun Ah
Huh, Kyoon
Choi, Jun Young
Usefulness of arterial spin labeling perfusion as an initial evaluation of status epilepticus
title Usefulness of arterial spin labeling perfusion as an initial evaluation of status epilepticus
title_full Usefulness of arterial spin labeling perfusion as an initial evaluation of status epilepticus
title_fullStr Usefulness of arterial spin labeling perfusion as an initial evaluation of status epilepticus
title_full_unstemmed Usefulness of arterial spin labeling perfusion as an initial evaluation of status epilepticus
title_short Usefulness of arterial spin labeling perfusion as an initial evaluation of status epilepticus
title_sort usefulness of arterial spin labeling perfusion as an initial evaluation of status epilepticus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688435/
https://www.ncbi.nlm.nih.gov/pubmed/34930959
http://dx.doi.org/10.1038/s41598-021-03698-7
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