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Usefulness of arterial spin labeling perfusion as an initial evaluation of status epilepticus
This study aimed to evaluate the sensitivity and prognostic value of arterial spin labeling (ASL) in a large group of status epilepticus (SE) patients and compare them with those of other magnetic resonance (MR) sequences, including dynamic susceptibility contrast (DSC) perfusion imaging. We retrosp...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688435/ https://www.ncbi.nlm.nih.gov/pubmed/34930959 http://dx.doi.org/10.1038/s41598-021-03698-7 |
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author | Kim, Tae-Joon Choi, Jin Wook Han, Miran Kim, Byung Gon Park, Sun Ah Huh, Kyoon Choi, Jun Young |
author_facet | Kim, Tae-Joon Choi, Jin Wook Han, Miran Kim, Byung Gon Park, Sun Ah Huh, Kyoon Choi, Jun Young |
author_sort | Kim, Tae-Joon |
collection | PubMed |
description | This study aimed to evaluate the sensitivity and prognostic value of arterial spin labeling (ASL) in a large group of status epilepticus (SE) patients and compare them with those of other magnetic resonance (MR) sequences, including dynamic susceptibility contrast (DSC) perfusion imaging. We retrospectively collected data of patients with SE in a tertiary center between September 2016 and March 2020. MR images were visually assessed, and the sensitivity for the detection of SE and prognostication was compared among multi-delay ASL, DSC, fluid-attenuated inversion recovery (FLAIR), and diffusion-weighted imaging (DWI). We included 51 SE patients and 46 patients with self-limiting seizures for comparison. Relevant changes in ASL were observed in 90.2% (46/51) of SE patients, a percentage higher than those for DSC, FLAIR, and DWI. ASL was the most sensitive method for initial differentiation between SE and self-limiting seizures. The sensitivity of ASL for detecting refractory SE (89.5%) or estimating poor outcomes (100%) was higher than those of other MR protocols or electroencephalography and comparable to those of clinical prognostic scores, although the specificity of ASL was very low as 9.4% and 15.6%, respectively. ASL showed a better ability to detect SE and predict the prognosis than other MR sequences, therefore it can be valuable for the initial evaluation of patients with SE. |
format | Online Article Text |
id | pubmed-8688435 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-86884352021-12-22 Usefulness of arterial spin labeling perfusion as an initial evaluation of status epilepticus Kim, Tae-Joon Choi, Jin Wook Han, Miran Kim, Byung Gon Park, Sun Ah Huh, Kyoon Choi, Jun Young Sci Rep Article This study aimed to evaluate the sensitivity and prognostic value of arterial spin labeling (ASL) in a large group of status epilepticus (SE) patients and compare them with those of other magnetic resonance (MR) sequences, including dynamic susceptibility contrast (DSC) perfusion imaging. We retrospectively collected data of patients with SE in a tertiary center between September 2016 and March 2020. MR images were visually assessed, and the sensitivity for the detection of SE and prognostication was compared among multi-delay ASL, DSC, fluid-attenuated inversion recovery (FLAIR), and diffusion-weighted imaging (DWI). We included 51 SE patients and 46 patients with self-limiting seizures for comparison. Relevant changes in ASL were observed in 90.2% (46/51) of SE patients, a percentage higher than those for DSC, FLAIR, and DWI. ASL was the most sensitive method for initial differentiation between SE and self-limiting seizures. The sensitivity of ASL for detecting refractory SE (89.5%) or estimating poor outcomes (100%) was higher than those of other MR protocols or electroencephalography and comparable to those of clinical prognostic scores, although the specificity of ASL was very low as 9.4% and 15.6%, respectively. ASL showed a better ability to detect SE and predict the prognosis than other MR sequences, therefore it can be valuable for the initial evaluation of patients with SE. Nature Publishing Group UK 2021-12-20 /pmc/articles/PMC8688435/ /pubmed/34930959 http://dx.doi.org/10.1038/s41598-021-03698-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Kim, Tae-Joon Choi, Jin Wook Han, Miran Kim, Byung Gon Park, Sun Ah Huh, Kyoon Choi, Jun Young Usefulness of arterial spin labeling perfusion as an initial evaluation of status epilepticus |
title | Usefulness of arterial spin labeling perfusion as an initial evaluation of status epilepticus |
title_full | Usefulness of arterial spin labeling perfusion as an initial evaluation of status epilepticus |
title_fullStr | Usefulness of arterial spin labeling perfusion as an initial evaluation of status epilepticus |
title_full_unstemmed | Usefulness of arterial spin labeling perfusion as an initial evaluation of status epilepticus |
title_short | Usefulness of arterial spin labeling perfusion as an initial evaluation of status epilepticus |
title_sort | usefulness of arterial spin labeling perfusion as an initial evaluation of status epilepticus |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688435/ https://www.ncbi.nlm.nih.gov/pubmed/34930959 http://dx.doi.org/10.1038/s41598-021-03698-7 |
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