BNIP3L/NIX-mediated mitophagy: molecular mechanisms and implications for human disease

Mitophagy is a highly conserved cellular process that maintains the mitochondrial quantity by eliminating dysfunctional or superfluous mitochondria through autophagy machinery. The mitochondrial outer membrane protein BNIP3L/Nix serves as a mitophagy receptor by recognizing autophagosomes. BNIP3L is...

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Autores principales: Li, Yue, Zheng, Wanqing, Lu, Yangyang, Zheng, Yanrong, Pan, Ling, Wu, Xiaoli, Yuan, Yang, Shen, Zhe, Ma, Shijia, Zhang, Xingxian, Wu, Jiaying, Chen, Zhong, Zhang, Xiangnan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688453/
https://www.ncbi.nlm.nih.gov/pubmed/34930907
http://dx.doi.org/10.1038/s41419-021-04469-y
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author Li, Yue
Zheng, Wanqing
Lu, Yangyang
Zheng, Yanrong
Pan, Ling
Wu, Xiaoli
Yuan, Yang
Shen, Zhe
Ma, Shijia
Zhang, Xingxian
Wu, Jiaying
Chen, Zhong
Zhang, Xiangnan
author_facet Li, Yue
Zheng, Wanqing
Lu, Yangyang
Zheng, Yanrong
Pan, Ling
Wu, Xiaoli
Yuan, Yang
Shen, Zhe
Ma, Shijia
Zhang, Xingxian
Wu, Jiaying
Chen, Zhong
Zhang, Xiangnan
author_sort Li, Yue
collection PubMed
description Mitophagy is a highly conserved cellular process that maintains the mitochondrial quantity by eliminating dysfunctional or superfluous mitochondria through autophagy machinery. The mitochondrial outer membrane protein BNIP3L/Nix serves as a mitophagy receptor by recognizing autophagosomes. BNIP3L is initially known to clear the mitochondria during the development of reticulocytes. Recent studies indicated it also engages in a variety of physiological and pathological processes. In this review, we provide an overview of how BNIP3L induces mitophagy and discuss the biological functions of BNIP3L and its regulation at the molecular level. We further discuss current evidence indicating the involvement of BNIP3L-mediated mitophagy in human disease, particularly in cancer and neurological disorders.
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spelling pubmed-86884532022-01-04 BNIP3L/NIX-mediated mitophagy: molecular mechanisms and implications for human disease Li, Yue Zheng, Wanqing Lu, Yangyang Zheng, Yanrong Pan, Ling Wu, Xiaoli Yuan, Yang Shen, Zhe Ma, Shijia Zhang, Xingxian Wu, Jiaying Chen, Zhong Zhang, Xiangnan Cell Death Dis Review Article Mitophagy is a highly conserved cellular process that maintains the mitochondrial quantity by eliminating dysfunctional or superfluous mitochondria through autophagy machinery. The mitochondrial outer membrane protein BNIP3L/Nix serves as a mitophagy receptor by recognizing autophagosomes. BNIP3L is initially known to clear the mitochondria during the development of reticulocytes. Recent studies indicated it also engages in a variety of physiological and pathological processes. In this review, we provide an overview of how BNIP3L induces mitophagy and discuss the biological functions of BNIP3L and its regulation at the molecular level. We further discuss current evidence indicating the involvement of BNIP3L-mediated mitophagy in human disease, particularly in cancer and neurological disorders. Nature Publishing Group UK 2021-12-20 /pmc/articles/PMC8688453/ /pubmed/34930907 http://dx.doi.org/10.1038/s41419-021-04469-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Li, Yue
Zheng, Wanqing
Lu, Yangyang
Zheng, Yanrong
Pan, Ling
Wu, Xiaoli
Yuan, Yang
Shen, Zhe
Ma, Shijia
Zhang, Xingxian
Wu, Jiaying
Chen, Zhong
Zhang, Xiangnan
BNIP3L/NIX-mediated mitophagy: molecular mechanisms and implications for human disease
title BNIP3L/NIX-mediated mitophagy: molecular mechanisms and implications for human disease
title_full BNIP3L/NIX-mediated mitophagy: molecular mechanisms and implications for human disease
title_fullStr BNIP3L/NIX-mediated mitophagy: molecular mechanisms and implications for human disease
title_full_unstemmed BNIP3L/NIX-mediated mitophagy: molecular mechanisms and implications for human disease
title_short BNIP3L/NIX-mediated mitophagy: molecular mechanisms and implications for human disease
title_sort bnip3l/nix-mediated mitophagy: molecular mechanisms and implications for human disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688453/
https://www.ncbi.nlm.nih.gov/pubmed/34930907
http://dx.doi.org/10.1038/s41419-021-04469-y
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