Cargando…

Transcriptomic and macroscopic architectures of intersubject functional variability in human brain white-matter

Intersubject variability is a fundamental characteristic of brain organizations, and not just “noise”. Although intrinsic functional connectivity (FC) is unique to each individual and varies across brain gray-matter, the underlying mechanisms of intersubject functional variability in white-matter (W...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Jiao, Wu, Guo-Rong, Li, Bing, Fan, Feiyang, Zhao, Xiaopeng, Meng, Yao, Zhong, Peng, Yang, Siqi, Biswal, Bharat B., Chen, Huafu, Liao, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688465/
https://www.ncbi.nlm.nih.gov/pubmed/34931033
http://dx.doi.org/10.1038/s42003-021-02952-y
_version_ 1784618357147828224
author Li, Jiao
Wu, Guo-Rong
Li, Bing
Fan, Feiyang
Zhao, Xiaopeng
Meng, Yao
Zhong, Peng
Yang, Siqi
Biswal, Bharat B.
Chen, Huafu
Liao, Wei
author_facet Li, Jiao
Wu, Guo-Rong
Li, Bing
Fan, Feiyang
Zhao, Xiaopeng
Meng, Yao
Zhong, Peng
Yang, Siqi
Biswal, Bharat B.
Chen, Huafu
Liao, Wei
author_sort Li, Jiao
collection PubMed
description Intersubject variability is a fundamental characteristic of brain organizations, and not just “noise”. Although intrinsic functional connectivity (FC) is unique to each individual and varies across brain gray-matter, the underlying mechanisms of intersubject functional variability in white-matter (WM) remain unknown. This study identified WMFC variabilities and determined the genetic basis and macroscale imaging in 45 healthy subjects. The functional localization pattern of intersubject variability across WM is heterogeneous, with most variability observed in the heteromodal cortex. The variabilities of heteromodal regions in expression profiles of genes are related to neuronal cells, involved in synapse-related and glutamic pathways, and associated with psychiatric disorders. In contrast, genes overexpressed in unimodal regions are mostly expressed in glial cells and were related to neurological diseases. Macroscopic variability recapitulates the functional and structural specializations and behavioral phenotypes. Together, our results provide clues to intersubject variabilities of the WMFC with convergent transcriptomic and cellular signatures, which relate to macroscale brain specialization.
format Online
Article
Text
id pubmed-8688465
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-86884652022-01-04 Transcriptomic and macroscopic architectures of intersubject functional variability in human brain white-matter Li, Jiao Wu, Guo-Rong Li, Bing Fan, Feiyang Zhao, Xiaopeng Meng, Yao Zhong, Peng Yang, Siqi Biswal, Bharat B. Chen, Huafu Liao, Wei Commun Biol Article Intersubject variability is a fundamental characteristic of brain organizations, and not just “noise”. Although intrinsic functional connectivity (FC) is unique to each individual and varies across brain gray-matter, the underlying mechanisms of intersubject functional variability in white-matter (WM) remain unknown. This study identified WMFC variabilities and determined the genetic basis and macroscale imaging in 45 healthy subjects. The functional localization pattern of intersubject variability across WM is heterogeneous, with most variability observed in the heteromodal cortex. The variabilities of heteromodal regions in expression profiles of genes are related to neuronal cells, involved in synapse-related and glutamic pathways, and associated with psychiatric disorders. In contrast, genes overexpressed in unimodal regions are mostly expressed in glial cells and were related to neurological diseases. Macroscopic variability recapitulates the functional and structural specializations and behavioral phenotypes. Together, our results provide clues to intersubject variabilities of the WMFC with convergent transcriptomic and cellular signatures, which relate to macroscale brain specialization. Nature Publishing Group UK 2021-12-20 /pmc/articles/PMC8688465/ /pubmed/34931033 http://dx.doi.org/10.1038/s42003-021-02952-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Li, Jiao
Wu, Guo-Rong
Li, Bing
Fan, Feiyang
Zhao, Xiaopeng
Meng, Yao
Zhong, Peng
Yang, Siqi
Biswal, Bharat B.
Chen, Huafu
Liao, Wei
Transcriptomic and macroscopic architectures of intersubject functional variability in human brain white-matter
title Transcriptomic and macroscopic architectures of intersubject functional variability in human brain white-matter
title_full Transcriptomic and macroscopic architectures of intersubject functional variability in human brain white-matter
title_fullStr Transcriptomic and macroscopic architectures of intersubject functional variability in human brain white-matter
title_full_unstemmed Transcriptomic and macroscopic architectures of intersubject functional variability in human brain white-matter
title_short Transcriptomic and macroscopic architectures of intersubject functional variability in human brain white-matter
title_sort transcriptomic and macroscopic architectures of intersubject functional variability in human brain white-matter
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688465/
https://www.ncbi.nlm.nih.gov/pubmed/34931033
http://dx.doi.org/10.1038/s42003-021-02952-y
work_keys_str_mv AT lijiao transcriptomicandmacroscopicarchitecturesofintersubjectfunctionalvariabilityinhumanbrainwhitematter
AT wuguorong transcriptomicandmacroscopicarchitecturesofintersubjectfunctionalvariabilityinhumanbrainwhitematter
AT libing transcriptomicandmacroscopicarchitecturesofintersubjectfunctionalvariabilityinhumanbrainwhitematter
AT fanfeiyang transcriptomicandmacroscopicarchitecturesofintersubjectfunctionalvariabilityinhumanbrainwhitematter
AT zhaoxiaopeng transcriptomicandmacroscopicarchitecturesofintersubjectfunctionalvariabilityinhumanbrainwhitematter
AT mengyao transcriptomicandmacroscopicarchitecturesofintersubjectfunctionalvariabilityinhumanbrainwhitematter
AT zhongpeng transcriptomicandmacroscopicarchitecturesofintersubjectfunctionalvariabilityinhumanbrainwhitematter
AT yangsiqi transcriptomicandmacroscopicarchitecturesofintersubjectfunctionalvariabilityinhumanbrainwhitematter
AT biswalbharatb transcriptomicandmacroscopicarchitecturesofintersubjectfunctionalvariabilityinhumanbrainwhitematter
AT chenhuafu transcriptomicandmacroscopicarchitecturesofintersubjectfunctionalvariabilityinhumanbrainwhitematter
AT liaowei transcriptomicandmacroscopicarchitecturesofintersubjectfunctionalvariabilityinhumanbrainwhitematter