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Body mass index but not genetic risk is longitudinally associated with altered structural brain parameters

Evidence from previous studies suggests that elevated body mass index (BMI) and genetic risk for obesity is associated with reduced brain volume, particularly in areas of reward-related cognition, e.g. the medial prefrontal cortex (AC-MPFC), the orbitofrontal cortex (OFC), the striatum and the thala...

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Autores principales: Tüngler, Anne, Van der Auwera, Sandra, Wittfeld, Katharina, Frenzel, Stefan, Terock, Jan, Röder, Nele, Homuth, Georg, Völzke, Henry, Bülow, Robin, Grabe, Hans Jörgen, Janowitz, Deborah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688483/
https://www.ncbi.nlm.nih.gov/pubmed/34930940
http://dx.doi.org/10.1038/s41598-021-03343-3
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author Tüngler, Anne
Van der Auwera, Sandra
Wittfeld, Katharina
Frenzel, Stefan
Terock, Jan
Röder, Nele
Homuth, Georg
Völzke, Henry
Bülow, Robin
Grabe, Hans Jörgen
Janowitz, Deborah
author_facet Tüngler, Anne
Van der Auwera, Sandra
Wittfeld, Katharina
Frenzel, Stefan
Terock, Jan
Röder, Nele
Homuth, Georg
Völzke, Henry
Bülow, Robin
Grabe, Hans Jörgen
Janowitz, Deborah
author_sort Tüngler, Anne
collection PubMed
description Evidence from previous studies suggests that elevated body mass index (BMI) and genetic risk for obesity is associated with reduced brain volume, particularly in areas of reward-related cognition, e.g. the medial prefrontal cortex (AC-MPFC), the orbitofrontal cortex (OFC), the striatum and the thalamus. However, only few studies examined the interplay between these factors in a joint approach. Moreover, previous findings are based on cross-sectional data. We investigated the longitudinal relationship between increased BMI, brain structural magnetic resonance imaging (MRI) parameters and genetic risk scores in a cohort of n = 502 community-dwelling participants from the Study of Health in Pomerania (SHIP) with a mean follow-up-time of 4.9 years. We found that (1) increased BMI values at baseline were associated with decreased brain parameters at follow-up. These effects were particularly pronounced for the OFC and AC-MPFC. (2) The genetic predisposition for BMI had no effect on brain parameters at baseline or follow-up. (3) The interaction between the genetic score for BMI and brain parameters had no effect on BMI at baseline. Finding a significant impact of overweight, but not genetic predisposition for obesity on altered brain structure suggests that metabolic mechanisms may underlie the relationship between obesity and altered brain structure.
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spelling pubmed-86884832021-12-22 Body mass index but not genetic risk is longitudinally associated with altered structural brain parameters Tüngler, Anne Van der Auwera, Sandra Wittfeld, Katharina Frenzel, Stefan Terock, Jan Röder, Nele Homuth, Georg Völzke, Henry Bülow, Robin Grabe, Hans Jörgen Janowitz, Deborah Sci Rep Article Evidence from previous studies suggests that elevated body mass index (BMI) and genetic risk for obesity is associated with reduced brain volume, particularly in areas of reward-related cognition, e.g. the medial prefrontal cortex (AC-MPFC), the orbitofrontal cortex (OFC), the striatum and the thalamus. However, only few studies examined the interplay between these factors in a joint approach. Moreover, previous findings are based on cross-sectional data. We investigated the longitudinal relationship between increased BMI, brain structural magnetic resonance imaging (MRI) parameters and genetic risk scores in a cohort of n = 502 community-dwelling participants from the Study of Health in Pomerania (SHIP) with a mean follow-up-time of 4.9 years. We found that (1) increased BMI values at baseline were associated with decreased brain parameters at follow-up. These effects were particularly pronounced for the OFC and AC-MPFC. (2) The genetic predisposition for BMI had no effect on brain parameters at baseline or follow-up. (3) The interaction between the genetic score for BMI and brain parameters had no effect on BMI at baseline. Finding a significant impact of overweight, but not genetic predisposition for obesity on altered brain structure suggests that metabolic mechanisms may underlie the relationship between obesity and altered brain structure. Nature Publishing Group UK 2021-12-20 /pmc/articles/PMC8688483/ /pubmed/34930940 http://dx.doi.org/10.1038/s41598-021-03343-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Tüngler, Anne
Van der Auwera, Sandra
Wittfeld, Katharina
Frenzel, Stefan
Terock, Jan
Röder, Nele
Homuth, Georg
Völzke, Henry
Bülow, Robin
Grabe, Hans Jörgen
Janowitz, Deborah
Body mass index but not genetic risk is longitudinally associated with altered structural brain parameters
title Body mass index but not genetic risk is longitudinally associated with altered structural brain parameters
title_full Body mass index but not genetic risk is longitudinally associated with altered structural brain parameters
title_fullStr Body mass index but not genetic risk is longitudinally associated with altered structural brain parameters
title_full_unstemmed Body mass index but not genetic risk is longitudinally associated with altered structural brain parameters
title_short Body mass index but not genetic risk is longitudinally associated with altered structural brain parameters
title_sort body mass index but not genetic risk is longitudinally associated with altered structural brain parameters
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688483/
https://www.ncbi.nlm.nih.gov/pubmed/34930940
http://dx.doi.org/10.1038/s41598-021-03343-3
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