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Autophagy deficiency promotes M1 macrophage polarization to exacerbate acute liver injury via ATG5 repression during aging

Aging disrupts the maintenance of liver homeostasis, which impairs hepatocyte regeneration and aggravates acute liver injury (ALI), ultimately leading to the development of acute liver failure (ALF), a systemic inflammatory response, and even death. Macrophages influence the progression and outcome...

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Detalles Bibliográficos
Autores principales:	Liu, Rui, Cui, Juanjuan, Sun, Yating, Xu, Wentao, Wang, Ziming, Wu, Miaomiao, Dong, Huke, Yang, Congcong, Hong, Shaocheng, Yin, Shi, Wang, Hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688512/ https://www.ncbi.nlm.nih.gov/pubmed/34930917 http://dx.doi.org/10.1038/s41420-021-00797-2

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