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Colorectal cancer-associated fibroblasts promote metastasis by up-regulating LRG1 through stromal IL-6/STAT3 signaling

Cancer-associated fibroblasts (CAFs) have been shown to play a strong role in colorectal cancer metastasis, yet the underlying mechanism remains to be fully elucidated. Using CRC clinical samples together with ex vivo CAFs-CRC co-culture models, we found that CAFs induce expression of Leucine Rich A...

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Detalles Bibliográficos
Autores principales:	Zhong, Beiping, Cheng, Bing, Huang, Xiaoming, Xiao, Qian, Niu, Zhitong, Chen, Yu-feng, Yu, Qiang, Wang, Wenyu, Wu, Xiao-Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688517/ https://www.ncbi.nlm.nih.gov/pubmed/34930899 http://dx.doi.org/10.1038/s41419-021-04461-6

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