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Targeting uPA-uPAR interaction to improve intestinal epithelial barrier integrity in inflammatory bowel disease

BACKGROUND: Loss of intestinal epithelial barrier integrity is a critical component of Inflammatory Bowel Disease (IBD) pathogenesis. Co-expression regulation of ligand-receptor pairs in IBD mucosa has not been systematically studied. Targeting ligand-receptor pairs which are induced in IBD mucosa a...

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Detalles Bibliográficos
Autores principales: Cheng, Yang, Hall, Tyler R., Xu, Xiao, Yung, Ivy, Souza, Donald, Zheng, Jie, Schiele, Felix, Hoffmann, Matthias, Mbow, M. Lamine, Garnett, James P., Li, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688562/
https://www.ncbi.nlm.nih.gov/pubmed/34933179
http://dx.doi.org/10.1016/j.ebiom.2021.103758

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