Trypsin-Mediated Sensitization to Ferroptosis Increases the Severity of Pancreatitis in Mice

BACKGROUND & AIMS: Pancreatitis is characterized by acinar cell death and persistent inflammation. Ferroptosis is a type of lipid peroxidation-dependent necrosis, which is negatively regulated by glutathione peroxidase 4. We studied how trypsin, a serine protease secreted by pancreatic acinar ce...

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Detalles Bibliográficos
Autores principales: Liu, Ke, Liu, Jiao, Zou, Borong, Li, Changfeng, Zeh, Herbert J., Kang, Rui, Kroemer, Guido, Huang, Jun, Tang, Daolin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688567/
https://www.ncbi.nlm.nih.gov/pubmed/34562639
http://dx.doi.org/10.1016/j.jcmgh.2021.09.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688567/
https://www.ncbi.nlm.nih.gov/pubmed/34562639
http://dx.doi.org/10.1016/j.jcmgh.2021.09.008

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