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Trypsin-Mediated Sensitization to Ferroptosis Increases the Severity of Pancreatitis in Mice
BACKGROUND & AIMS: Pancreatitis is characterized by acinar cell death and persistent inflammation. Ferroptosis is a type of lipid peroxidation-dependent necrosis, which is negatively regulated by glutathione peroxidase 4. We studied how trypsin, a serine protease secreted by pancreatic acinar ce...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688567/ https://www.ncbi.nlm.nih.gov/pubmed/34562639 http://dx.doi.org/10.1016/j.jcmgh.2021.09.008 |