A highly conserved zebrafish IMPDH retinal isoform produces the majority of guanine and forms dynamic protein filaments in photoreceptor cells

Inosine monophosphate dehydrogenase (IMPDH) is a key regulatory enzyme in the de novo synthesis of the purine base guanine. Dominant mutations in human IMPDH1 cause photoreceptor degeneration for reasons that are unknown. Here, we sought to provide some foundational information on Impdh1a in the zeb...

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Detalles Bibliográficos
Autores principales: Cleghorn, Whitney M., Burrell, Anika L., Giarmarco, Michelle M., Brock, Daniel C., Wang, Yekai, Chambers, Zachary S., Du, Jianhai, Kollman, Justin M., Brockerhoff, Susan E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688572/
https://www.ncbi.nlm.nih.gov/pubmed/34813793
http://dx.doi.org/10.1016/j.jbc.2021.101441

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