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Long Term Impact on Lung Function of Patients With Moderate and Severe COVID-19. A Prospective Cohort Study

Background: In Pakistan, the cases of COVID-19 have declined from 6000 per day in June to 600 in September 2020. A significant number of patients continue to recover from the disease, however, little is known about the lung function capacity among survivors. We aim to determine the long-term impact...

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Autores principales: Qureshi, Sonia, Nasir, Nosheen, Rashid, Naveed, Ahmed, Naveed, Haq, Zoya, Qamar, Farah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688692/
https://www.ncbi.nlm.nih.gov/pubmed/34950621
http://dx.doi.org/10.3389/fpubh.2021.663076
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author Qureshi, Sonia
Nasir, Nosheen
Rashid, Naveed
Ahmed, Naveed
Haq, Zoya
Qamar, Farah
author_facet Qureshi, Sonia
Nasir, Nosheen
Rashid, Naveed
Ahmed, Naveed
Haq, Zoya
Qamar, Farah
author_sort Qureshi, Sonia
collection PubMed
description Background: In Pakistan, the cases of COVID-19 have declined from 6000 per day in June to 600 in September 2020. A significant number of patients continue to recover from the disease, however, little is known about the lung function capacity among survivors. We aim to determine the long-term impact on lung function capacity in patients who have survived moderate or severe COVID-19 disease in a resource-poor setting. Methods: This prospective cohort study will be conducted at Aga Khan University Hospital (AKUH), Karachi Pakistan. Patients 15 years and above who have survived an episode of moderate or severe COVID-19, have reverse transcriptase-polymerase chain reaction (RT-PCR) positive for COVID 19 (nasopharyngeal or oropharyngeal) will be included. Patients with a pre-existing diagnosis of obstructive or interstitial lung disease, lung fibrosis, lung cancers, connective tissue disorders, autoimmune conditions affecting the lungs, underlying heart disease, history of syncope and those who refuse to participate will be excluded from the study. Pulmonary function will be assessed using spirometry and diffusion lung capacity for carbon monoxide (DLCO) at 3- and 6-months interval from the time of discharge from the hospital. Additionally, a chest X-ray and CT-chest will be performed if clinically indicated after consultation with the study pulmonologist or Infectious Disease (ID) physician. Echocardiogram (ECHO) will be performed to look for pulmonary hypertension at the 3 month visit and repeated at 6 months in case any abnormality is identified in the initial ECHO. Data analysis will be performed using standard statistical software. The study was approved by the Ethical Review Committee (ERC) of the institution (ERC reference number 2020-4735-11311). Strengths and Limitations of the Study: This cohort study will provide evidence on the long-term impact on lung function among COVID-19 survivors with moderate to severe disease. Such data will be key in understanding the impact of the disease on vital functions and will help devise rehabilitative strategies to best overcome the effects of disease. However, this will be a single-center, study recruiting only a limited number of COVID-19 survivors.
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spelling pubmed-86886922021-12-22 Long Term Impact on Lung Function of Patients With Moderate and Severe COVID-19. A Prospective Cohort Study Qureshi, Sonia Nasir, Nosheen Rashid, Naveed Ahmed, Naveed Haq, Zoya Qamar, Farah Front Public Health Public Health Background: In Pakistan, the cases of COVID-19 have declined from 6000 per day in June to 600 in September 2020. A significant number of patients continue to recover from the disease, however, little is known about the lung function capacity among survivors. We aim to determine the long-term impact on lung function capacity in patients who have survived moderate or severe COVID-19 disease in a resource-poor setting. Methods: This prospective cohort study will be conducted at Aga Khan University Hospital (AKUH), Karachi Pakistan. Patients 15 years and above who have survived an episode of moderate or severe COVID-19, have reverse transcriptase-polymerase chain reaction (RT-PCR) positive for COVID 19 (nasopharyngeal or oropharyngeal) will be included. Patients with a pre-existing diagnosis of obstructive or interstitial lung disease, lung fibrosis, lung cancers, connective tissue disorders, autoimmune conditions affecting the lungs, underlying heart disease, history of syncope and those who refuse to participate will be excluded from the study. Pulmonary function will be assessed using spirometry and diffusion lung capacity for carbon monoxide (DLCO) at 3- and 6-months interval from the time of discharge from the hospital. Additionally, a chest X-ray and CT-chest will be performed if clinically indicated after consultation with the study pulmonologist or Infectious Disease (ID) physician. Echocardiogram (ECHO) will be performed to look for pulmonary hypertension at the 3 month visit and repeated at 6 months in case any abnormality is identified in the initial ECHO. Data analysis will be performed using standard statistical software. The study was approved by the Ethical Review Committee (ERC) of the institution (ERC reference number 2020-4735-11311). Strengths and Limitations of the Study: This cohort study will provide evidence on the long-term impact on lung function among COVID-19 survivors with moderate to severe disease. Such data will be key in understanding the impact of the disease on vital functions and will help devise rehabilitative strategies to best overcome the effects of disease. However, this will be a single-center, study recruiting only a limited number of COVID-19 survivors. Frontiers Media S.A. 2021-12-07 /pmc/articles/PMC8688692/ /pubmed/34950621 http://dx.doi.org/10.3389/fpubh.2021.663076 Text en Copyright © 2021 Qureshi, Nasir, Rashid, Ahmed, Haq and Qamar. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Qureshi, Sonia
Nasir, Nosheen
Rashid, Naveed
Ahmed, Naveed
Haq, Zoya
Qamar, Farah
Long Term Impact on Lung Function of Patients With Moderate and Severe COVID-19. A Prospective Cohort Study
title Long Term Impact on Lung Function of Patients With Moderate and Severe COVID-19. A Prospective Cohort Study
title_full Long Term Impact on Lung Function of Patients With Moderate and Severe COVID-19. A Prospective Cohort Study
title_fullStr Long Term Impact on Lung Function of Patients With Moderate and Severe COVID-19. A Prospective Cohort Study
title_full_unstemmed Long Term Impact on Lung Function of Patients With Moderate and Severe COVID-19. A Prospective Cohort Study
title_short Long Term Impact on Lung Function of Patients With Moderate and Severe COVID-19. A Prospective Cohort Study
title_sort long term impact on lung function of patients with moderate and severe covid-19. a prospective cohort study
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688692/
https://www.ncbi.nlm.nih.gov/pubmed/34950621
http://dx.doi.org/10.3389/fpubh.2021.663076
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