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Long Non-Coding RNAs, Novel Offenders or Guardians in Multiple Sclerosis: A Scoping Review
Multiple sclerosis (MS), a chronic inflammatory demyelinating disease of the central nervous system, is one of the most common neurodegenerative diseases worldwide. MS results in serious neurological dysfunctions and disability. Disturbances in coding and non-coding genes are key components leading...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688805/ https://www.ncbi.nlm.nih.gov/pubmed/34950142 http://dx.doi.org/10.3389/fimmu.2021.774002 |
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author | Jalaiei, Abbas Asadi, Mohammad Reza Sabaie, Hani Dehghani, Hossein Gharesouran, Jalal Hussen, Bashdar Mahmud Taheri, Mohammad Ghafouri-Fard, Soudeh Rezazadeh, Maryam |
author_facet | Jalaiei, Abbas Asadi, Mohammad Reza Sabaie, Hani Dehghani, Hossein Gharesouran, Jalal Hussen, Bashdar Mahmud Taheri, Mohammad Ghafouri-Fard, Soudeh Rezazadeh, Maryam |
author_sort | Jalaiei, Abbas |
collection | PubMed |
description | Multiple sclerosis (MS), a chronic inflammatory demyelinating disease of the central nervous system, is one of the most common neurodegenerative diseases worldwide. MS results in serious neurological dysfunctions and disability. Disturbances in coding and non-coding genes are key components leading to neurodegeneration along with environmental factors. Long non-coding RNAs (lncRNAs) are long molecules in cells that take part in the regulation of gene expression. Several studies have confirmed the role of lncRNAs in neurodegenerative diseases such as MS. In the current study, we performed a systematic analysis of the role of lncRNAs in this disorder. In total, 53 studies were recognized as eligible for this systematic review. Of the listed lncRNAs, 52 lncRNAs were upregulated, 37 lncRNAs were downregulated, and 11 lncRNAs had no significant expression difference in MS patients compared with controls. We also summarized some of the mechanisms of lncRNA functions in MS. The emerging role of lncRNAs in neurodegenerative diseases suggests that their dysregulation could trigger neuronal death via still unexplored RNA-based regulatory mechanisms. Evaluation of their diagnostic significance and therapeutic potential could help in the design of novel treatments for MS. |
format | Online Article Text |
id | pubmed-8688805 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86888052021-12-22 Long Non-Coding RNAs, Novel Offenders or Guardians in Multiple Sclerosis: A Scoping Review Jalaiei, Abbas Asadi, Mohammad Reza Sabaie, Hani Dehghani, Hossein Gharesouran, Jalal Hussen, Bashdar Mahmud Taheri, Mohammad Ghafouri-Fard, Soudeh Rezazadeh, Maryam Front Immunol Immunology Multiple sclerosis (MS), a chronic inflammatory demyelinating disease of the central nervous system, is one of the most common neurodegenerative diseases worldwide. MS results in serious neurological dysfunctions and disability. Disturbances in coding and non-coding genes are key components leading to neurodegeneration along with environmental factors. Long non-coding RNAs (lncRNAs) are long molecules in cells that take part in the regulation of gene expression. Several studies have confirmed the role of lncRNAs in neurodegenerative diseases such as MS. In the current study, we performed a systematic analysis of the role of lncRNAs in this disorder. In total, 53 studies were recognized as eligible for this systematic review. Of the listed lncRNAs, 52 lncRNAs were upregulated, 37 lncRNAs were downregulated, and 11 lncRNAs had no significant expression difference in MS patients compared with controls. We also summarized some of the mechanisms of lncRNA functions in MS. The emerging role of lncRNAs in neurodegenerative diseases suggests that their dysregulation could trigger neuronal death via still unexplored RNA-based regulatory mechanisms. Evaluation of their diagnostic significance and therapeutic potential could help in the design of novel treatments for MS. Frontiers Media S.A. 2021-12-07 /pmc/articles/PMC8688805/ /pubmed/34950142 http://dx.doi.org/10.3389/fimmu.2021.774002 Text en Copyright © 2021 Jalaiei, Asadi, Sabaie, Dehghani, Gharesouran, Hussen, Taheri, Ghafouri-Fard and Rezazadeh https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Jalaiei, Abbas Asadi, Mohammad Reza Sabaie, Hani Dehghani, Hossein Gharesouran, Jalal Hussen, Bashdar Mahmud Taheri, Mohammad Ghafouri-Fard, Soudeh Rezazadeh, Maryam Long Non-Coding RNAs, Novel Offenders or Guardians in Multiple Sclerosis: A Scoping Review |
title | Long Non-Coding RNAs, Novel Offenders or Guardians in Multiple Sclerosis: A Scoping Review |
title_full | Long Non-Coding RNAs, Novel Offenders or Guardians in Multiple Sclerosis: A Scoping Review |
title_fullStr | Long Non-Coding RNAs, Novel Offenders or Guardians in Multiple Sclerosis: A Scoping Review |
title_full_unstemmed | Long Non-Coding RNAs, Novel Offenders or Guardians in Multiple Sclerosis: A Scoping Review |
title_short | Long Non-Coding RNAs, Novel Offenders or Guardians in Multiple Sclerosis: A Scoping Review |
title_sort | long non-coding rnas, novel offenders or guardians in multiple sclerosis: a scoping review |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688805/ https://www.ncbi.nlm.nih.gov/pubmed/34950142 http://dx.doi.org/10.3389/fimmu.2021.774002 |
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