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High expression of uracil DNA glycosylase determines C to T substitution in human pluripotent stem cells

Precise genome editing of human pluripotent stem cells (hPSCs) is crucial not only for basic science but also for biomedical applications such as ex vivo stem cell therapy and genetic disease modeling. However, hPSCs have unique cellular properties compared to somatic cells. For instance, hPSCs are...

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Detalles Bibliográficos
Autores principales:	Park, Ju-Chan, Jang, Hyeon-Ki, Kim, Jumee, Han, Jun Hee, Jung, Youngri, Kim, Keuntae, Bae, Sangsu, Cha, Hyuk-Jin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688811/ https://www.ncbi.nlm.nih.gov/pubmed/34976436 http://dx.doi.org/10.1016/j.omtn.2021.11.023

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