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Epigenetic Studies of Chinese Herbal Medicine: Pleiotropic Role of DNA Methylation

Accumulating knowledge has been achieved on DNA methylation participating in numerous cellular processes and multiple human diseases; however, few studies have addressed the pleiotropic role of DNA methylation in Chinese herbal medicine (CHM). CHM has been used worldwide for the prevention and treat...

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Autores principales: Guo, Wenqian, Ma, Han, Wang, Chong-Zhi, Wan, Jin-Yi, Yao, Haiqiang, Yuan, Chun-Su
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688941/
https://www.ncbi.nlm.nih.gov/pubmed/34950039
http://dx.doi.org/10.3389/fphar.2021.790321
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author Guo, Wenqian
Ma, Han
Wang, Chong-Zhi
Wan, Jin-Yi
Yao, Haiqiang
Yuan, Chun-Su
author_facet Guo, Wenqian
Ma, Han
Wang, Chong-Zhi
Wan, Jin-Yi
Yao, Haiqiang
Yuan, Chun-Su
author_sort Guo, Wenqian
collection PubMed
description Accumulating knowledge has been achieved on DNA methylation participating in numerous cellular processes and multiple human diseases; however, few studies have addressed the pleiotropic role of DNA methylation in Chinese herbal medicine (CHM). CHM has been used worldwide for the prevention and treatment of multiple diseases. Newly developed epigenetic techniques have brought great opportunities for the development of CHM. In this review, we summarize the DNA methylation studies and portray the pleiotropic role of DNA methylation in CHM. DNA methylation serves as a mediator participating in plant responses to environmental factors, and thus affecting CHM medicinal plants growth and bioactive compound biosynthesis which are vital for therapeutic effects. Furthermore, DNA methylation helps to uncover the pharmaceutical mechanisms of CHM formulae, herbs, and herbal-derived compounds. It also provides scientific validation for constitution theory and other essential issues of CHM. This newly developed field of DNA methylation is up-and-coming to address many complicated scientific questions of CHM; it thus not only promotes disease treatment but also facilitates health maintenance.
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spelling pubmed-86889412021-12-22 Epigenetic Studies of Chinese Herbal Medicine: Pleiotropic Role of DNA Methylation Guo, Wenqian Ma, Han Wang, Chong-Zhi Wan, Jin-Yi Yao, Haiqiang Yuan, Chun-Su Front Pharmacol Pharmacology Accumulating knowledge has been achieved on DNA methylation participating in numerous cellular processes and multiple human diseases; however, few studies have addressed the pleiotropic role of DNA methylation in Chinese herbal medicine (CHM). CHM has been used worldwide for the prevention and treatment of multiple diseases. Newly developed epigenetic techniques have brought great opportunities for the development of CHM. In this review, we summarize the DNA methylation studies and portray the pleiotropic role of DNA methylation in CHM. DNA methylation serves as a mediator participating in plant responses to environmental factors, and thus affecting CHM medicinal plants growth and bioactive compound biosynthesis which are vital for therapeutic effects. Furthermore, DNA methylation helps to uncover the pharmaceutical mechanisms of CHM formulae, herbs, and herbal-derived compounds. It also provides scientific validation for constitution theory and other essential issues of CHM. This newly developed field of DNA methylation is up-and-coming to address many complicated scientific questions of CHM; it thus not only promotes disease treatment but also facilitates health maintenance. Frontiers Media S.A. 2021-12-07 /pmc/articles/PMC8688941/ /pubmed/34950039 http://dx.doi.org/10.3389/fphar.2021.790321 Text en Copyright © 2021 Guo, Ma, Wang, Wan, Yao and Yuan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Guo, Wenqian
Ma, Han
Wang, Chong-Zhi
Wan, Jin-Yi
Yao, Haiqiang
Yuan, Chun-Su
Epigenetic Studies of Chinese Herbal Medicine: Pleiotropic Role of DNA Methylation
title Epigenetic Studies of Chinese Herbal Medicine: Pleiotropic Role of DNA Methylation
title_full Epigenetic Studies of Chinese Herbal Medicine: Pleiotropic Role of DNA Methylation
title_fullStr Epigenetic Studies of Chinese Herbal Medicine: Pleiotropic Role of DNA Methylation
title_full_unstemmed Epigenetic Studies of Chinese Herbal Medicine: Pleiotropic Role of DNA Methylation
title_short Epigenetic Studies of Chinese Herbal Medicine: Pleiotropic Role of DNA Methylation
title_sort epigenetic studies of chinese herbal medicine: pleiotropic role of dna methylation
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688941/
https://www.ncbi.nlm.nih.gov/pubmed/34950039
http://dx.doi.org/10.3389/fphar.2021.790321
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