Oncolytic adenovirus-mediated expression of decorin facilitates CAIX-targeting CAR-T therapy against renal cell carcinoma

Although chimeric antigen receptor T cell (CAR-T) therapy has been successful for hematological malignancies, it is less effective for solid tumors. The primary reason is that the immune microenvironment restricts CAR-T cells from infiltrating and proliferating in tumors. Oncolytic virotherapy has e...

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Detalles Bibliográficos
Autores principales: Zhang, Chen, Fang, Lin, Wang, Xueyan, Yuan, Sen, Li, Wanjing, Tian, Weiping, Chen, Jing, Zhang, Qi, Zhang, Yuxin, Zhang, Qing, Zheng, Junnian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688951/
https://www.ncbi.nlm.nih.gov/pubmed/34977339
http://dx.doi.org/10.1016/j.omto.2021.11.018

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