Cargando…

Five Constituents Contributed to the Psoraleae Fructus-Induced Hepatotoxicity via Mitochondrial Dysfunction and Apoptosis

Backgrounds: Psoraleae Fructus (PF)-induced hepatotoxicity has been reported in clinical and animal experiments. However, the hepatotoxic constituents and mechanisms underlying PF-induced toxicity have remained unclear. Therefore, this study explored the potentially toxic PF components and revealed...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guo, Zhaojuan, Li, Pin, Wang, Chunguo, Kang, Qianjun, Tu, Can, Jiang, Bingqian, Zhang, Jingxuan, Wang, Weiling, Wang, Ting
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8688997/ https://www.ncbi.nlm.nih.gov/pubmed/34950022 http://dx.doi.org/10.3389/fphar.2021.682823

Ejemplares similares

Psoraleae Fructus Ethanol Extract Induced Hepatotoxicity via Impaired Lipid Metabolism Caused by Disruption of Fatty Acid β-Oxidation
por: Guo, Zhaojuan, et al.
Publicado: (2023)

General survey of Fructus Psoraleae from the different origins and chemical identification of the roasted from raw Fructus Psoraleae
por: Yang, Junjun, et al.
Publicado: (2017)

Research on the Species Difference of the Hepatotoxicity of Medicine Based on Transcriptome
por: Xu, Ziying, et al.
Publicado: (2021)

Analysis of the absorbed constituents and mechanism of liquidambaris fructus extract on hepatocellular carcinoma
por: Wang, Shuai, et al.
Publicado: (2022)

The Extract of Fructus Psoraleae Promotes Viability and Cartilaginous Formation of Rat Chondrocytes In Vitro
por: Pan, Xin, et al.
Publicado: (2016)

Five Constituents in Psoralea corylifolia L. Attenuate Palmitic Acid-Induced Hepatocyte Injury via Inhibiting the Protein Kinase C-α/Nicotinamide-Adenine Dinucleotide Phosphate Oxidase Pathway
por: Zhou, Lishan, et al.
Publicado: (2020)

Epimedium koreanum Nakai–Induced Liver Injury—A Mechanistic Study Using Untargeted Metabolomics
por: Li, Pin, et al.
Publicado: (2022)

Hepatotoxicity Comparison of Crude and Licorice-Processed Euodiae Fructus in Rats With Stomach Excess-Cold Syndrome
por: Zhang, Min, et al.
Publicado: (2021)

Effects of Fructus Psoraleae Extract on the Intestinal Absorption Kinetics of Geniposide and Geniposidic Acid in Rat
por: Huo, Yan, et al.
Publicado: (2014)

Multi-Omics Integration to Reveal the Mechanism of Hepatotoxicity Induced by Dictamnine
por: Tu, Can, et al.
Publicado: (2021)

Quality Assessment of Psoralea fructus by HPLC Fingerprint Coupled with Multi-components Analysis
por: Yin, F. Z., et al.
Publicado: (2015)

Separation, identification, and quantification of active constituents in Fructus Psoraleae by high-performance liquid chromatography with UV, ion trap mass spectrometry, and electrochemical detection
por: Chen, Qinhua, et al.
Publicado: (2012)

Protective Effects and Possible Mechanisms of Actions of Bushen Cuyun Recipe on Diminished Ovarian Reserve Induced by Cyclophosphamide in Rats
por: Jiang, Mei, et al.
Publicado: (2020)

Multi-Target Anti-Alzheimer Activities of Four Prenylated Compounds from Psoralea Fructus
por: Xu, Qing-Xia, et al.
Publicado: (2018)

Acute liver failure associated with Fructus Psoraleae: a case report and literature review
por: Li, Ang, et al.
Publicado: (2019)

New bakuchiol dimers from Psoraleae Fructus and their inhibitory activities on nitric oxide production
por: Xu, Qingxia, et al.
Publicado: (2021)

Psoralea corylifolia L. Attenuates Nonalcoholic Steatohepatitis in Juvenile Mouse
por: Zhou, Lishan, et al.
Publicado: (2017)

Quantitative analysis, pharmacokinetics and metabolomics study for the comprehensive characterization of the salt-processing mechanism of Psoraleae Fructus
por: Li, Kai, et al.
Publicado: (2019)

Ionic Liquid-Based Ultrasonic-Assisted Extraction to Analyze Seven Compounds in Psoralea Fructus Coupled with HPLC
por: Shi, Mengjun, et al.
Publicado: (2019)

UPLC-MS/MS-Based Rat Serum Metabolomics Reveals the Detoxification Mechanism of Psoraleae Fructus during Salt Processing
por: Wang, Dan, et al.
Publicado: (2021)

Constituents of Psoralea corylifolia Fruits and Their Effects on Methicillin-Resistant Staphylococcus aureus
por: Cui, Yanmei, et al.
Publicado: (2015)

Antibacterial constituents of Fructus Chebulae Immaturus and their mechanisms of action
por: Li, Kun, et al.
Publicado: (2016)

In vitro Anti-viral Activity of Psoraleae Semen Water Extract against Influenza A Viruses
por: Choi, Jang-gi, et al.
Publicado: (2016)

The Evaluation of Toxicity Induced by Psoraleae Fructus in Rats Using Untargeted Metabonomic Method Based on UPLC-Q-TOF/MS
por: Xu, Yanyan, et al.
Publicado: (2017)

Better detoxifying effect of ripe forsythiae fructus over green forsythiae fructus and the potential mechanisms involving bile acids metabolism and gut microbiota
por: Wang, Tao, et al.
Publicado: (2022)

Effects and Mechanisms of Five Psoralea Prenylflavonoids on Aging-Related Diseases
por: Zhou, Yi-Ting, et al.
Publicado: (2020)

Antiobesity Potential of Bioactive Constituents from Dichloromethane Extract of Psoralea corylifolia L. Seeds
por: Mahajan, Neha, et al.
Publicado: (2022)

Corni Fructus: a review of chemical constituents and pharmacological activities
por: Dong, Yu, et al.
Publicado: (2018)

Anti-cancer activity of Psoralea fructus through the downregulation of cyclin D1 and CDK4 in human colorectal cancer cells
por: Park, Gwang Hun, et al.
Publicado: (2016)

Chiral separation of bavachinin in Fructus Psoraleae and rat plasma by liquid chromatography using permethylated-β-CD as a chiral selector
por: Liu, Jing-Jing, et al.
Publicado: (2013)

Antiosteoporosis Effect and Possible Mechanisms of the Ingredients of Fructus Psoraleae in Animal Models of Osteoporosis: A Preclinical Systematic Review and Meta-Analysis
por: Lin, Zhou, et al.
Publicado: (2021)

Bruceae Fructus Oil Inhibits Triple-Negative Breast Cancer by Restraining Autophagy: Dependence on the Gut Microbiota-Mediated Amino Acid Regulation
por: Su, Jiyan, et al.
Publicado: (2021)

Bioactive Chemical Constituents and Pharmacological Activities of Ponciri Fructus
por: Lamichhane, Gopal, et al.
Publicado: (2022)

Potential cardiotoxicity induced by Euodiae Fructus: In vivo and in vitro experiments and untargeted metabolomics research
por: Zhang, Dan, et al.
Publicado: (2022)

Xiongshao Zhitong Recipe Attenuates Nitroglycerin-Induced Migraine-Like Behaviors via the Inhibition of Inflammation Mediated by Nitric Oxide Synthase
por: Yang, Song, et al.
Publicado: (2022)

Subchronic Toxicity Studies of Cortex Dictamni Extracts in Mice and Its Potential Hepatotoxicity Mechanisms in Vitro
por: Fan, Qiongyin, et al.
Publicado: (2018)

Distribution Patterns for Bioactive Constituents in Pericarp, Stalk and Seed of Forsythiae Fructus
por: Wei, Lifang, et al.
Publicado: (2020)

Luteolin Alleviates Methamphetamine-Induced Hepatotoxicity by Suppressing the p53 Pathway-Mediated Apoptosis, Autophagy, and Inflammation in Rats
por: Zhang, Kai-Kai, et al.
Publicado: (2021)

Genistein From Fructus sophorae Protects Mice From Radiation-Induced Intestinal Injury
por: Zhang, Jieyu, et al.
Publicado: (2021)

The Chemical Constituents of Diaphragma Juglandis Fructus and Their Inhibitory Effect on α-Glucosidase Activity
por: Tan, Jinyan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_6hn1th1ja11p79iq5k12o9idec