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Regulatory B Cell Therapy in Kidney Transplantation
In the context of kidney injury, the role of Bregs is gaining interest. In a number of autoimmune diseases, the number and/or the function of Bregs has been shown to be impaired or downregulated, therefore restoring their balance might be a potential therapeutic tool. Moreover, in the context of kid...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689004/ https://www.ncbi.nlm.nih.gov/pubmed/34950041 http://dx.doi.org/10.3389/fphar.2021.791450 |
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author | Garcia, Sergio G. Sandoval-Hellín, Noelia Franquesa, Marcella |
author_facet | Garcia, Sergio G. Sandoval-Hellín, Noelia Franquesa, Marcella |
author_sort | Garcia, Sergio G. |
collection | PubMed |
description | In the context of kidney injury, the role of Bregs is gaining interest. In a number of autoimmune diseases, the number and/or the function of Bregs has been shown to be impaired or downregulated, therefore restoring their balance might be a potential therapeutic tool. Moreover, in the context of kidney transplantation their upregulation has been linked to tolerance. However, a specific marker or set of markers that define Bregs as a unique cell subset has not been found and otherwise multiple phenotypes of Bregs have been studied. A quest on the proper markers and induction mechanisms is now the goal of many researchers. Here we summarize the most recent evidence on the role of Bregs in kidney disease by describing the relevance of in vitro and in vivo Bregs induction as well as the potential use of Bregs as cell therapy agents in kidney transplantation. |
format | Online Article Text |
id | pubmed-8689004 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86890042021-12-22 Regulatory B Cell Therapy in Kidney Transplantation Garcia, Sergio G. Sandoval-Hellín, Noelia Franquesa, Marcella Front Pharmacol Pharmacology In the context of kidney injury, the role of Bregs is gaining interest. In a number of autoimmune diseases, the number and/or the function of Bregs has been shown to be impaired or downregulated, therefore restoring their balance might be a potential therapeutic tool. Moreover, in the context of kidney transplantation their upregulation has been linked to tolerance. However, a specific marker or set of markers that define Bregs as a unique cell subset has not been found and otherwise multiple phenotypes of Bregs have been studied. A quest on the proper markers and induction mechanisms is now the goal of many researchers. Here we summarize the most recent evidence on the role of Bregs in kidney disease by describing the relevance of in vitro and in vivo Bregs induction as well as the potential use of Bregs as cell therapy agents in kidney transplantation. Frontiers Media S.A. 2021-12-07 /pmc/articles/PMC8689004/ /pubmed/34950041 http://dx.doi.org/10.3389/fphar.2021.791450 Text en Copyright © 2021 Garcia, Sandoval-Hellín and Franquesa. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Garcia, Sergio G. Sandoval-Hellín, Noelia Franquesa, Marcella Regulatory B Cell Therapy in Kidney Transplantation |
title | Regulatory B Cell Therapy in Kidney Transplantation |
title_full | Regulatory B Cell Therapy in Kidney Transplantation |
title_fullStr | Regulatory B Cell Therapy in Kidney Transplantation |
title_full_unstemmed | Regulatory B Cell Therapy in Kidney Transplantation |
title_short | Regulatory B Cell Therapy in Kidney Transplantation |
title_sort | regulatory b cell therapy in kidney transplantation |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689004/ https://www.ncbi.nlm.nih.gov/pubmed/34950041 http://dx.doi.org/10.3389/fphar.2021.791450 |
work_keys_str_mv | AT garciasergiog regulatorybcelltherapyinkidneytransplantation AT sandovalhellinnoelia regulatorybcelltherapyinkidneytransplantation AT franquesamarcella regulatorybcelltherapyinkidneytransplantation |