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Chitosan Nanoparticles for Antiviral Drug Delivery: A Novel Route for COVID-19 Treatment

Chitosan has been investigated in several biological fields, including drug and gene delivery, tissue engineering antiviral and immunological adjuvant methods. It’s a cationic copolymer of N-acetyl glucosamine and D-glucosamine with different molecular chain lengths, compositions, and sequences than...

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Detalles Bibliográficos
Autores principales: Safer, Abdel-Majed, Leporatti, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689047/
https://www.ncbi.nlm.nih.gov/pubmed/34949922
http://dx.doi.org/10.2147/IJN.S332385
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author Safer, Abdel-Majed
Leporatti, Stefano
author_facet Safer, Abdel-Majed
Leporatti, Stefano
author_sort Safer, Abdel-Majed
collection PubMed
description Chitosan has been investigated in several biological fields, including drug and gene delivery, tissue engineering antiviral and immunological adjuvant methods. It’s a cationic copolymer of N-acetyl glucosamine and D-glucosamine with different molecular chain lengths, compositions, and sequences than N-acetyl glucosamine and D-glucosamine. It is biocompatible and cyto-compatible, as well as recyclable and bioresorbable. As effective drug delivery methods, chitosan nanoparticles are shaped into several pathways. The purpose of this article is to provide an overview of its antiviral application as a nanocarrier for antiviral medications, highlighting the benefits, limitations, and downsides. In this review, we will report the most recent COVID-19 vaccination advances. It will also be discussed what the future holds for chitosan nanoparticles in the treatment of coronaviruses.
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spelling pubmed-86890472021-12-22 Chitosan Nanoparticles for Antiviral Drug Delivery: A Novel Route for COVID-19 Treatment Safer, Abdel-Majed Leporatti, Stefano Int J Nanomedicine Review Chitosan has been investigated in several biological fields, including drug and gene delivery, tissue engineering antiviral and immunological adjuvant methods. It’s a cationic copolymer of N-acetyl glucosamine and D-glucosamine with different molecular chain lengths, compositions, and sequences than N-acetyl glucosamine and D-glucosamine. It is biocompatible and cyto-compatible, as well as recyclable and bioresorbable. As effective drug delivery methods, chitosan nanoparticles are shaped into several pathways. The purpose of this article is to provide an overview of its antiviral application as a nanocarrier for antiviral medications, highlighting the benefits, limitations, and downsides. In this review, we will report the most recent COVID-19 vaccination advances. It will also be discussed what the future holds for chitosan nanoparticles in the treatment of coronaviruses. Dove 2021-12-16 /pmc/articles/PMC8689047/ /pubmed/34949922 http://dx.doi.org/10.2147/IJN.S332385 Text en © 2021 Safer and Leporatti. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Safer, Abdel-Majed
Leporatti, Stefano
Chitosan Nanoparticles for Antiviral Drug Delivery: A Novel Route for COVID-19 Treatment
title Chitosan Nanoparticles for Antiviral Drug Delivery: A Novel Route for COVID-19 Treatment
title_full Chitosan Nanoparticles for Antiviral Drug Delivery: A Novel Route for COVID-19 Treatment
title_fullStr Chitosan Nanoparticles for Antiviral Drug Delivery: A Novel Route for COVID-19 Treatment
title_full_unstemmed Chitosan Nanoparticles for Antiviral Drug Delivery: A Novel Route for COVID-19 Treatment
title_short Chitosan Nanoparticles for Antiviral Drug Delivery: A Novel Route for COVID-19 Treatment
title_sort chitosan nanoparticles for antiviral drug delivery: a novel route for covid-19 treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689047/
https://www.ncbi.nlm.nih.gov/pubmed/34949922
http://dx.doi.org/10.2147/IJN.S332385
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