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Chitosan Nanoparticles for Antiviral Drug Delivery: A Novel Route for COVID-19 Treatment
Chitosan has been investigated in several biological fields, including drug and gene delivery, tissue engineering antiviral and immunological adjuvant methods. It’s a cationic copolymer of N-acetyl glucosamine and D-glucosamine with different molecular chain lengths, compositions, and sequences than...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689047/ https://www.ncbi.nlm.nih.gov/pubmed/34949922 http://dx.doi.org/10.2147/IJN.S332385 |
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author | Safer, Abdel-Majed Leporatti, Stefano |
author_facet | Safer, Abdel-Majed Leporatti, Stefano |
author_sort | Safer, Abdel-Majed |
collection | PubMed |
description | Chitosan has been investigated in several biological fields, including drug and gene delivery, tissue engineering antiviral and immunological adjuvant methods. It’s a cationic copolymer of N-acetyl glucosamine and D-glucosamine with different molecular chain lengths, compositions, and sequences than N-acetyl glucosamine and D-glucosamine. It is biocompatible and cyto-compatible, as well as recyclable and bioresorbable. As effective drug delivery methods, chitosan nanoparticles are shaped into several pathways. The purpose of this article is to provide an overview of its antiviral application as a nanocarrier for antiviral medications, highlighting the benefits, limitations, and downsides. In this review, we will report the most recent COVID-19 vaccination advances. It will also be discussed what the future holds for chitosan nanoparticles in the treatment of coronaviruses. |
format | Online Article Text |
id | pubmed-8689047 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-86890472021-12-22 Chitosan Nanoparticles for Antiviral Drug Delivery: A Novel Route for COVID-19 Treatment Safer, Abdel-Majed Leporatti, Stefano Int J Nanomedicine Review Chitosan has been investigated in several biological fields, including drug and gene delivery, tissue engineering antiviral and immunological adjuvant methods. It’s a cationic copolymer of N-acetyl glucosamine and D-glucosamine with different molecular chain lengths, compositions, and sequences than N-acetyl glucosamine and D-glucosamine. It is biocompatible and cyto-compatible, as well as recyclable and bioresorbable. As effective drug delivery methods, chitosan nanoparticles are shaped into several pathways. The purpose of this article is to provide an overview of its antiviral application as a nanocarrier for antiviral medications, highlighting the benefits, limitations, and downsides. In this review, we will report the most recent COVID-19 vaccination advances. It will also be discussed what the future holds for chitosan nanoparticles in the treatment of coronaviruses. Dove 2021-12-16 /pmc/articles/PMC8689047/ /pubmed/34949922 http://dx.doi.org/10.2147/IJN.S332385 Text en © 2021 Safer and Leporatti. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Review Safer, Abdel-Majed Leporatti, Stefano Chitosan Nanoparticles for Antiviral Drug Delivery: A Novel Route for COVID-19 Treatment |
title | Chitosan Nanoparticles for Antiviral Drug Delivery: A Novel Route for COVID-19 Treatment |
title_full | Chitosan Nanoparticles for Antiviral Drug Delivery: A Novel Route for COVID-19 Treatment |
title_fullStr | Chitosan Nanoparticles for Antiviral Drug Delivery: A Novel Route for COVID-19 Treatment |
title_full_unstemmed | Chitosan Nanoparticles for Antiviral Drug Delivery: A Novel Route for COVID-19 Treatment |
title_short | Chitosan Nanoparticles for Antiviral Drug Delivery: A Novel Route for COVID-19 Treatment |
title_sort | chitosan nanoparticles for antiviral drug delivery: a novel route for covid-19 treatment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689047/ https://www.ncbi.nlm.nih.gov/pubmed/34949922 http://dx.doi.org/10.2147/IJN.S332385 |
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