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A high-fat diet catalyzes progression to hyperglycemia in mice with selective impairment of insulin action in Glut4-expressing tissues

Insulin resistance impairs postprandial glucose uptake through glucose transporter type 4 (GLUT4) and is the primary defect preceding type 2 diabetes. We previously generated an insulin-resistant mouse model with human GLUT4 promoter-driven insulin receptor knockout (GIRKO) in the muscle, adipose, a...

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Detalles Bibliográficos
Autores principales:	Reilly, Austin M., Yan, Shijun, Huang, Menghao, Abhyankar, Surabhi D., Conley, Jason M., Bone, Robert N., Stull, Natalie D., Horan, Daniel J., Roh, Hyun C., Robling, Alexander G., Ericsson, Aaron C., Dong, Xiaocheng C., Evans-Molina, Carmella, Ren, Hongxia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689209/ https://www.ncbi.nlm.nih.gov/pubmed/34801552 http://dx.doi.org/10.1016/j.jbc.2021.101431

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