Anorectic and aversive effects of GLP-1 receptor agonism are mediated by brainstem cholecystokinin neurons, and modulated by GIP receptor activation

OBJECTIVE: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are effective medications to reduce appetite and body weight. These actions are centrally mediated; however, the neuronal substrates involved are poorly understood. METHODS: We employed a combination of neuroanatomical, genetic, and beh...

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Detalles Bibliográficos
Autores principales: Costa, Alessia, Ai, Minrong, Nunn, Nicolas, Culotta, Isabella, Hunter, Jenna, Boudjadja, Mehdi Boutagouga, Valencia-Torres, Lourdes, Aviello, Gabriella, Hodson, David J., Snider, Brandy M., Coskun, Tamer, Emmerson, Paul J., Luckman, Simon M., D'Agostino, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689241/
https://www.ncbi.nlm.nih.gov/pubmed/34844019
http://dx.doi.org/10.1016/j.molmet.2021.101407

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