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Prevalence, prognostic value, pathophysiology, and management of hyponatraemia in children and adolescents with COVID-19
Hyponatraemia is frequently encountered in adults with coronavirus disease 2019 (COVID-19) and is associated with poor prognosis. This review aims to describe for the first time the prevalence, aetiology, prognostic value, pathophysiology, and management of hyponatraemia in children and adolescents...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Mattioli 1885
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689294/ https://www.ncbi.nlm.nih.gov/pubmed/34738553 http://dx.doi.org/10.23750/abm.v92i5.12330 |
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author | Tzoulis, Ploutarchos |
author_facet | Tzoulis, Ploutarchos |
author_sort | Tzoulis, Ploutarchos |
collection | PubMed |
description | Hyponatraemia is frequently encountered in adults with coronavirus disease 2019 (COVID-19) and is associated with poor prognosis. This review aims to describe for the first time the prevalence, aetiology, prognostic value, pathophysiology, and management of hyponatraemia in children and adolescents with COVID-19, taking into account all relevant studies published in PubMed and Cochrane Library studies until 26(th) September 2021. Literature search did not detect any studies evaluating the prevalence and prognostic value of sodium disorders in paediatric patients with COVID-19. A broader literature review showed a high prevalence of hyponatraemia in children with bacterial pneumonia, while some studies have reported that hyponatraemia is relatively common in Multisystem Inflammatory Syndrome in Children (MIS-C). In adults with COVID-19, an inverse association between sodium and interleukin-6 levels has been found, indicating that hyponatraemia could be used as a surrogate marker for the risk of cytokine storm and may facilitate the identification of patients who could benefit from immunomodulatory agents. Studies are urgently needed to evaluate the frequency and prognostic impact of electrolyte abnormalities in children with COVID-19. In the meantime, clinicians are urged to consider hyponatraemia in children with COVID-19 as a potential red flag, investigate the cause and administer fluids and other therapies accordingly. (www.actabiomedica.it) |
format | Online Article Text |
id | pubmed-8689294 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Mattioli 1885 |
record_format | MEDLINE/PubMed |
spelling | pubmed-86892942022-01-06 Prevalence, prognostic value, pathophysiology, and management of hyponatraemia in children and adolescents with COVID-19 Tzoulis, Ploutarchos Acta Biomed Pediatric Endocrinology Update (Editor: Vincenzo De Sanctis) Hyponatraemia is frequently encountered in adults with coronavirus disease 2019 (COVID-19) and is associated with poor prognosis. This review aims to describe for the first time the prevalence, aetiology, prognostic value, pathophysiology, and management of hyponatraemia in children and adolescents with COVID-19, taking into account all relevant studies published in PubMed and Cochrane Library studies until 26(th) September 2021. Literature search did not detect any studies evaluating the prevalence and prognostic value of sodium disorders in paediatric patients with COVID-19. A broader literature review showed a high prevalence of hyponatraemia in children with bacterial pneumonia, while some studies have reported that hyponatraemia is relatively common in Multisystem Inflammatory Syndrome in Children (MIS-C). In adults with COVID-19, an inverse association between sodium and interleukin-6 levels has been found, indicating that hyponatraemia could be used as a surrogate marker for the risk of cytokine storm and may facilitate the identification of patients who could benefit from immunomodulatory agents. Studies are urgently needed to evaluate the frequency and prognostic impact of electrolyte abnormalities in children with COVID-19. In the meantime, clinicians are urged to consider hyponatraemia in children with COVID-19 as a potential red flag, investigate the cause and administer fluids and other therapies accordingly. (www.actabiomedica.it) Mattioli 1885 2021 2021-11-03 /pmc/articles/PMC8689294/ /pubmed/34738553 http://dx.doi.org/10.23750/abm.v92i5.12330 Text en Copyright: © 2021 ACTA BIO MEDICA SOCIETY OF MEDICINE AND NATURAL SCIENCES OF PARMA https://creativecommons.org/licenses/by-nc-sa/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License |
spellingShingle | Pediatric Endocrinology Update (Editor: Vincenzo De Sanctis) Tzoulis, Ploutarchos Prevalence, prognostic value, pathophysiology, and management of hyponatraemia in children and adolescents with COVID-19 |
title | Prevalence, prognostic value, pathophysiology, and management of hyponatraemia in children and adolescents with COVID-19 |
title_full | Prevalence, prognostic value, pathophysiology, and management of hyponatraemia in children and adolescents with COVID-19 |
title_fullStr | Prevalence, prognostic value, pathophysiology, and management of hyponatraemia in children and adolescents with COVID-19 |
title_full_unstemmed | Prevalence, prognostic value, pathophysiology, and management of hyponatraemia in children and adolescents with COVID-19 |
title_short | Prevalence, prognostic value, pathophysiology, and management of hyponatraemia in children and adolescents with COVID-19 |
title_sort | prevalence, prognostic value, pathophysiology, and management of hyponatraemia in children and adolescents with covid-19 |
topic | Pediatric Endocrinology Update (Editor: Vincenzo De Sanctis) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689294/ https://www.ncbi.nlm.nih.gov/pubmed/34738553 http://dx.doi.org/10.23750/abm.v92i5.12330 |
work_keys_str_mv | AT tzoulisploutarchos prevalenceprognosticvaluepathophysiologyandmanagementofhyponatraemiainchildrenandadolescentswithcovid19 |