Toward a Practical, Nonenzymatic Process for Investigational COVID-19 Antiviral Molnupiravir from Cytidine: Supply-Centered Synthesis

[Image: see text] A scalable four-step synthesis of molnupiravir from cytidine is described herein. The attractiveness of this approach is its fully chemical nature involving inexpensive reagents and more environmentally friendly solvents such as water, isopropanol, acetonitrile, and acetone. Isolat...

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Detalles Bibliográficos
Autores principales: Gopalsamuthiram, Vijayagopal, Kadam, Appasaheb L., Noble, Jeffrey K., Snead, David R., Williams, Corshai, Jamison, Timothy F., Senanayake, Chris, Yadaw, Ajay K., Roy, Sarabindu, Sirasani, Gopal, Gupton, B. Frank, Burns, Justina, Cook, Daniel W., Stringham, Rodger W., Ahmad, Saeed, Krack, Rudy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689649/
https://www.ncbi.nlm.nih.gov/pubmed/34955627
http://dx.doi.org/10.1021/acs.oprd.1c00219

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