Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis

Metastasis is the major cause of death in cancer patients. Circulating tumor cells need to migrate through the endothelial layer of blood vessels to escape the hostile circulation and establish metastases at distant organ sites. Here, we identified the membrane-bound metalloprotease ADAM17 on endoth...

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Detalles Bibliográficos
Autores principales: Bolik, Julia, Krause, Freia, Stevanovic, Marija, Gandraß, Monja, Thomsen, Ilka, Schacht, Sarah-Sophie, Rieser, Eva, Müller, Miryam, Schumacher, Neele, Fritsch, Jürgen, Wichert, Rielana, Galun, Eithan, Bergmann, Juri, Röder, Christian, Schafmayer, Clemens, Egberts, Jan-Hendrik, Becker-Pauly, Christoph, Saftig, Paul, Lucius, Ralph, Schneider-Brachert, Wulf, Barikbin, Roja, Adam, Dieter, Voss, Matthias, Hitzl, Wolfgang, Krüger, Achim, Strilic, Boris, Sagi, Irit, Walczak, Henning, Rose-John, Stefan, Schmidt-Arras, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689681/
https://www.ncbi.nlm.nih.gov/pubmed/34919140
http://dx.doi.org/10.1084/jem.20201039

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