Temporal Dynamics of Anti–Type 1 Interferon Autoantibodies in Patients With Coronavirus Disease 2019

Binding levels and neutralization activity of anti–type 1 interferon autoantibodies peaked during acute coronavirus disease 2019 and markedly decreased thereafter. Most patients maintained some ability to neutralize type 1 interferon into convalescence despite lower levels of binding immunoglobulin...

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Autores principales: Shaw, Elana R, Rosen, Lindsey B, Cheng, Aristine, Dobbs, Kerry, Delmonte, Ottavia M, Ferré, Elise M N, Schmitt, Monica M, Imberti, Luisa, Quaresima, Virginia, Lionakis, Michail S, Notarangelo, Luigi D, Holland, Steven M, Su, Helen C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689695/
https://www.ncbi.nlm.nih.gov/pubmed/34875033
http://dx.doi.org/10.1093/cid/ciab1002
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author Shaw, Elana R
Rosen, Lindsey B
Cheng, Aristine
Dobbs, Kerry
Delmonte, Ottavia M
Ferré, Elise M N
Schmitt, Monica M
Imberti, Luisa
Quaresima, Virginia
Lionakis, Michail S
Notarangelo, Luigi D
Holland, Steven M
Su, Helen C
author_facet Shaw, Elana R
Rosen, Lindsey B
Cheng, Aristine
Dobbs, Kerry
Delmonte, Ottavia M
Ferré, Elise M N
Schmitt, Monica M
Imberti, Luisa
Quaresima, Virginia
Lionakis, Michail S
Notarangelo, Luigi D
Holland, Steven M
Su, Helen C
author_sort Shaw, Elana R
collection PubMed
description Binding levels and neutralization activity of anti–type 1 interferon autoantibodies peaked during acute coronavirus disease 2019 and markedly decreased thereafter. Most patients maintained some ability to neutralize type 1 interferon into convalescence despite lower levels of binding immunoglobulin G. Identifying these autoantibodies in healthy individuals before the development of critical viral disease may be challenging.
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spelling pubmed-86896952022-01-05 Temporal Dynamics of Anti–Type 1 Interferon Autoantibodies in Patients With Coronavirus Disease 2019 Shaw, Elana R Rosen, Lindsey B Cheng, Aristine Dobbs, Kerry Delmonte, Ottavia M Ferré, Elise M N Schmitt, Monica M Imberti, Luisa Quaresima, Virginia Lionakis, Michail S Notarangelo, Luigi D Holland, Steven M Su, Helen C Clin Infect Dis Brief Report Binding levels and neutralization activity of anti–type 1 interferon autoantibodies peaked during acute coronavirus disease 2019 and markedly decreased thereafter. Most patients maintained some ability to neutralize type 1 interferon into convalescence despite lower levels of binding immunoglobulin G. Identifying these autoantibodies in healthy individuals before the development of critical viral disease may be challenging. Oxford University Press 2021-12-07 /pmc/articles/PMC8689695/ /pubmed/34875033 http://dx.doi.org/10.1093/cid/ciab1002 Text en Published by Oxford University Press for the Infectious Diseases Society of America 2021. This work is written by (a) US Government employee(s) and is in the public domain in the US.
spellingShingle Brief Report
Shaw, Elana R
Rosen, Lindsey B
Cheng, Aristine
Dobbs, Kerry
Delmonte, Ottavia M
Ferré, Elise M N
Schmitt, Monica M
Imberti, Luisa
Quaresima, Virginia
Lionakis, Michail S
Notarangelo, Luigi D
Holland, Steven M
Su, Helen C
Temporal Dynamics of Anti–Type 1 Interferon Autoantibodies in Patients With Coronavirus Disease 2019
title Temporal Dynamics of Anti–Type 1 Interferon Autoantibodies in Patients With Coronavirus Disease 2019
title_full Temporal Dynamics of Anti–Type 1 Interferon Autoantibodies in Patients With Coronavirus Disease 2019
title_fullStr Temporal Dynamics of Anti–Type 1 Interferon Autoantibodies in Patients With Coronavirus Disease 2019
title_full_unstemmed Temporal Dynamics of Anti–Type 1 Interferon Autoantibodies in Patients With Coronavirus Disease 2019
title_short Temporal Dynamics of Anti–Type 1 Interferon Autoantibodies in Patients With Coronavirus Disease 2019
title_sort temporal dynamics of anti–type 1 interferon autoantibodies in patients with coronavirus disease 2019
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689695/
https://www.ncbi.nlm.nih.gov/pubmed/34875033
http://dx.doi.org/10.1093/cid/ciab1002
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