Hyperinflammatory Syndromes After Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Messenger RNA vaccination in Individuals With Underlying Immune Dysregulation

The development of effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) messenger RNA (mRNA) vaccines has been a significant accomplishment. Adverse events are extremely rare, but continued surveillance is important, especially in at-risk populations. In 5 patients with preexisting...

Descripción completa

Detalles Bibliográficos
Autores principales: Rocco, Joseph M, Mallarino-Haeger, Christina, Randolph, Attiya H, Ray, Susan M, Schechter, Marcos C, Zerbe, Christa S, Holland, Steven M, Sereti, Irini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689836/
https://www.ncbi.nlm.nih.gov/pubmed/34893818
http://dx.doi.org/10.1093/cid/ciab1024
_version_ 1784618595325575168
author Rocco, Joseph M
Mallarino-Haeger, Christina
Randolph, Attiya H
Ray, Susan M
Schechter, Marcos C
Zerbe, Christa S
Holland, Steven M
Sereti, Irini
author_facet Rocco, Joseph M
Mallarino-Haeger, Christina
Randolph, Attiya H
Ray, Susan M
Schechter, Marcos C
Zerbe, Christa S
Holland, Steven M
Sereti, Irini
author_sort Rocco, Joseph M
collection PubMed
description The development of effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) messenger RNA (mRNA) vaccines has been a significant accomplishment. Adverse events are extremely rare, but continued surveillance is important, especially in at-risk populations. In 5 patients with preexisting immune dysregulation, hyperinflammatory syndromes, including hemophagocytic lymphohistiocytosis, developed after SARS-CoV-2 mRNA vaccination. Early recognition of this rare condition is essential.
format Online
Article
Text
id pubmed-8689836
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-86898362022-01-05 Hyperinflammatory Syndromes After Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Messenger RNA vaccination in Individuals With Underlying Immune Dysregulation Rocco, Joseph M Mallarino-Haeger, Christina Randolph, Attiya H Ray, Susan M Schechter, Marcos C Zerbe, Christa S Holland, Steven M Sereti, Irini Clin Infect Dis Brief Report The development of effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) messenger RNA (mRNA) vaccines has been a significant accomplishment. Adverse events are extremely rare, but continued surveillance is important, especially in at-risk populations. In 5 patients with preexisting immune dysregulation, hyperinflammatory syndromes, including hemophagocytic lymphohistiocytosis, developed after SARS-CoV-2 mRNA vaccination. Early recognition of this rare condition is essential. Oxford University Press 2021-12-10 /pmc/articles/PMC8689836/ /pubmed/34893818 http://dx.doi.org/10.1093/cid/ciab1024 Text en Published by Oxford University Press for the Infectious Diseases Society of America 2021. This work is written by (a) US Government employee(s) and is in the public domain in the US.
spellingShingle Brief Report
Rocco, Joseph M
Mallarino-Haeger, Christina
Randolph, Attiya H
Ray, Susan M
Schechter, Marcos C
Zerbe, Christa S
Holland, Steven M
Sereti, Irini
Hyperinflammatory Syndromes After Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Messenger RNA vaccination in Individuals With Underlying Immune Dysregulation
title Hyperinflammatory Syndromes After Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Messenger RNA vaccination in Individuals With Underlying Immune Dysregulation
title_full Hyperinflammatory Syndromes After Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Messenger RNA vaccination in Individuals With Underlying Immune Dysregulation
title_fullStr Hyperinflammatory Syndromes After Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Messenger RNA vaccination in Individuals With Underlying Immune Dysregulation
title_full_unstemmed Hyperinflammatory Syndromes After Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Messenger RNA vaccination in Individuals With Underlying Immune Dysregulation
title_short Hyperinflammatory Syndromes After Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Messenger RNA vaccination in Individuals With Underlying Immune Dysregulation
title_sort hyperinflammatory syndromes after severe acute respiratory syndrome coronavirus 2 (sars-cov-2) messenger rna vaccination in individuals with underlying immune dysregulation
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689836/
https://www.ncbi.nlm.nih.gov/pubmed/34893818
http://dx.doi.org/10.1093/cid/ciab1024
work_keys_str_mv AT roccojosephm hyperinflammatorysyndromesaftersevereacuterespiratorysyndromecoronavirus2sarscov2messengerrnavaccinationinindividualswithunderlyingimmunedysregulation
AT mallarinohaegerchristina hyperinflammatorysyndromesaftersevereacuterespiratorysyndromecoronavirus2sarscov2messengerrnavaccinationinindividualswithunderlyingimmunedysregulation
AT randolphattiyah hyperinflammatorysyndromesaftersevereacuterespiratorysyndromecoronavirus2sarscov2messengerrnavaccinationinindividualswithunderlyingimmunedysregulation
AT raysusanm hyperinflammatorysyndromesaftersevereacuterespiratorysyndromecoronavirus2sarscov2messengerrnavaccinationinindividualswithunderlyingimmunedysregulation
AT schechtermarcosc hyperinflammatorysyndromesaftersevereacuterespiratorysyndromecoronavirus2sarscov2messengerrnavaccinationinindividualswithunderlyingimmunedysregulation
AT zerbechristas hyperinflammatorysyndromesaftersevereacuterespiratorysyndromecoronavirus2sarscov2messengerrnavaccinationinindividualswithunderlyingimmunedysregulation
AT hollandstevenm hyperinflammatorysyndromesaftersevereacuterespiratorysyndromecoronavirus2sarscov2messengerrnavaccinationinindividualswithunderlyingimmunedysregulation
AT seretiirini hyperinflammatorysyndromesaftersevereacuterespiratorysyndromecoronavirus2sarscov2messengerrnavaccinationinindividualswithunderlyingimmunedysregulation

Ejemplares similares