Urban Particulate Matter Impairment of Airway Surface Liquid–Mediated Coronavirus Inactivation

Air pollution particulate matter (PM) is associated with SARS-CoV-2 infection and severity, although mechanistic studies are lacking. We tested whether airway surface liquid (ASL) from primary human airway epithelial cells is antiviral against SARS-CoV-2 and human alphacoronavirus 229E (CoV-229E) (r...

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Detalles Bibliográficos
Autores principales: Stapleton, Emma M, Welch, Jennifer L, Ubeda, Erika A, Xiang, Jinhua, Zabner, Joseph, Thornell, Ian M, Nonnenmann, Matthew W, Stapleton, Jack T, Comellas, Alejandro P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689861/
https://www.ncbi.nlm.nih.gov/pubmed/34734257
http://dx.doi.org/10.1093/infdis/jiab545
Descripción
Sumario:Air pollution particulate matter (PM) is associated with SARS-CoV-2 infection and severity, although mechanistic studies are lacking. We tested whether airway surface liquid (ASL) from primary human airway epithelial cells is antiviral against SARS-CoV-2 and human alphacoronavirus 229E (CoV-229E) (responsible for common colds), and whether PM (urban, indoor air pollution [IAP], volcanic ash) affected ASL antiviral activity. ASL inactivated SARS-CoV-2 and CoV-229E. Independently, urban PM also decreased SARS-CoV-2 and CoV-229E infection, and IAP PM decreased CoV-229E infection. However, in combination, urban PM impaired ASL’s antiviral activity against both viruses, and the same effect occurred for IAP PM and ash against SARS-CoV-2, suggesting that PM may enhance SARS-CoV-2 infection.

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