Effects of Severe Acute Respiratory Syndrome Coronavirus 2 Strain Variation on Virus Neutralization Titers: Therapeutic Use of Convalescent Plasma

We compared neutralizing antibody titers of convalescent samples collected before and after the emergence of novel strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), against the wild-type virus and Alpha (B.1.1.7) and Beta (B.1.351) variants. Plasma samples collected in 2020 be...

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Autores principales: Nguyen, Dung, Xiao, Julie, Simmonds, Peter, Lamikanra, Abigail, Odon, Valerie, Ratcliff, Jeremy, Townsend, Alain, Roberts, David J, Harvala, Heli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689936/
https://www.ncbi.nlm.nih.gov/pubmed/34751775
http://dx.doi.org/10.1093/infdis/jiab563
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author Nguyen, Dung
Xiao, Julie
Simmonds, Peter
Lamikanra, Abigail
Odon, Valerie
Ratcliff, Jeremy
Townsend, Alain
Roberts, David J
Harvala, Heli
author_facet Nguyen, Dung
Xiao, Julie
Simmonds, Peter
Lamikanra, Abigail
Odon, Valerie
Ratcliff, Jeremy
Townsend, Alain
Roberts, David J
Harvala, Heli
author_sort Nguyen, Dung
collection PubMed
description We compared neutralizing antibody titers of convalescent samples collected before and after the emergence of novel strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), against the wild-type virus and Alpha (B.1.1.7) and Beta (B.1.351) variants. Plasma samples collected in 2020 before emergence of variants showed reduced titers against the Alpha variants, and both sets of samples demonstrated significantly reduced titers against Beta. Comparison of microneutralization titers with those obtained with pseudotype and hemagglutination tests showed a good correlation between their titers and effects of strain variation, supporting the use of these simpler assays for assessing the potency of convalescent plasma against currently circulating and emerging strains of SARS-CoV-2.
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spelling pubmed-86899362022-01-05 Effects of Severe Acute Respiratory Syndrome Coronavirus 2 Strain Variation on Virus Neutralization Titers: Therapeutic Use of Convalescent Plasma Nguyen, Dung Xiao, Julie Simmonds, Peter Lamikanra, Abigail Odon, Valerie Ratcliff, Jeremy Townsend, Alain Roberts, David J Harvala, Heli J Infect Dis Major Articles and Brief Reports We compared neutralizing antibody titers of convalescent samples collected before and after the emergence of novel strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), against the wild-type virus and Alpha (B.1.1.7) and Beta (B.1.351) variants. Plasma samples collected in 2020 before emergence of variants showed reduced titers against the Alpha variants, and both sets of samples demonstrated significantly reduced titers against Beta. Comparison of microneutralization titers with those obtained with pseudotype and hemagglutination tests showed a good correlation between their titers and effects of strain variation, supporting the use of these simpler assays for assessing the potency of convalescent plasma against currently circulating and emerging strains of SARS-CoV-2. Oxford University Press 2021-11-09 /pmc/articles/PMC8689936/ /pubmed/34751775 http://dx.doi.org/10.1093/infdis/jiab563 Text en © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Major Articles and Brief Reports
Nguyen, Dung
Xiao, Julie
Simmonds, Peter
Lamikanra, Abigail
Odon, Valerie
Ratcliff, Jeremy
Townsend, Alain
Roberts, David J
Harvala, Heli
Effects of Severe Acute Respiratory Syndrome Coronavirus 2 Strain Variation on Virus Neutralization Titers: Therapeutic Use of Convalescent Plasma
title Effects of Severe Acute Respiratory Syndrome Coronavirus 2 Strain Variation on Virus Neutralization Titers: Therapeutic Use of Convalescent Plasma
title_full Effects of Severe Acute Respiratory Syndrome Coronavirus 2 Strain Variation on Virus Neutralization Titers: Therapeutic Use of Convalescent Plasma
title_fullStr Effects of Severe Acute Respiratory Syndrome Coronavirus 2 Strain Variation on Virus Neutralization Titers: Therapeutic Use of Convalescent Plasma
title_full_unstemmed Effects of Severe Acute Respiratory Syndrome Coronavirus 2 Strain Variation on Virus Neutralization Titers: Therapeutic Use of Convalescent Plasma
title_short Effects of Severe Acute Respiratory Syndrome Coronavirus 2 Strain Variation on Virus Neutralization Titers: Therapeutic Use of Convalescent Plasma
title_sort effects of severe acute respiratory syndrome coronavirus 2 strain variation on virus neutralization titers: therapeutic use of convalescent plasma
topic Major Articles and Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689936/
https://www.ncbi.nlm.nih.gov/pubmed/34751775
http://dx.doi.org/10.1093/infdis/jiab563
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