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Coronavirus Disease 2019 Messenger RNA Vaccine Immunogenicity in Immunosuppressed Individuals
Individuals on immunosuppressive (IS) therapy have increased mortality from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and delayed viral clearance may lead to new viral variants. IS therapy reduces antibody responses following coronavirus disease 2019 (COVID-19) messenge...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8690024/ https://www.ncbi.nlm.nih.gov/pubmed/34792136 http://dx.doi.org/10.1093/infdis/jiab569 |
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| author | Collier, Ai-ris Y Yu, Jingyou McMahan, Katherine Liu, Jinyan Atyeo, Caroline Ansel, Jessica L Fricker, Zachary P Pavlakis, Martha Curry, Michael P Jacob-Dolan, Catherine Patel, Het Sellers, Daniel Barrett, Julia Rowe, Marjorie Ahmad, Kunza Gompers, Annika Aguayo, Ricardo Chandrashekar, Abishek Alter, Galit Hacker, Michele R Barouch, Dan H |
| author_facet | Collier, Ai-ris Y Yu, Jingyou McMahan, Katherine Liu, Jinyan Atyeo, Caroline Ansel, Jessica L Fricker, Zachary P Pavlakis, Martha Curry, Michael P Jacob-Dolan, Catherine Patel, Het Sellers, Daniel Barrett, Julia Rowe, Marjorie Ahmad, Kunza Gompers, Annika Aguayo, Ricardo Chandrashekar, Abishek Alter, Galit Hacker, Michele R Barouch, Dan H |
| author_sort | Collier, Ai-ris Y |
| collection | PubMed |
| description | Individuals on immunosuppressive (IS) therapy have increased mortality from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and delayed viral clearance may lead to new viral variants. IS therapy reduces antibody responses following coronavirus disease 2019 (COVID-19) messenger RNA (mRNA) vaccination; however, a comprehensive assessment of vaccine immunogenicity is lacking. Here we show that IS therapy reduced neutralizing, binding, and nonneutralizing antibody functions in addition to CD4 and CD8 T-cell interferon-γ responses following COVID-19 mRNA vaccination compared to immunocompetent individuals. Moreover, IS therapy reduced cross-reactivity against SARS-CoV-2 variants. These data suggest that the standard COVID-19 mRNA vaccine regimens will likely not provide optimal protection in immunocompromised individuals. |
| format | Online Article Text |
| id | pubmed-8690024 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Oxford University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-86900242022-01-05 Coronavirus Disease 2019 Messenger RNA Vaccine Immunogenicity in Immunosuppressed Individuals Collier, Ai-ris Y Yu, Jingyou McMahan, Katherine Liu, Jinyan Atyeo, Caroline Ansel, Jessica L Fricker, Zachary P Pavlakis, Martha Curry, Michael P Jacob-Dolan, Catherine Patel, Het Sellers, Daniel Barrett, Julia Rowe, Marjorie Ahmad, Kunza Gompers, Annika Aguayo, Ricardo Chandrashekar, Abishek Alter, Galit Hacker, Michele R Barouch, Dan H J Infect Dis Major Articles and Brief Reports Individuals on immunosuppressive (IS) therapy have increased mortality from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and delayed viral clearance may lead to new viral variants. IS therapy reduces antibody responses following coronavirus disease 2019 (COVID-19) messenger RNA (mRNA) vaccination; however, a comprehensive assessment of vaccine immunogenicity is lacking. Here we show that IS therapy reduced neutralizing, binding, and nonneutralizing antibody functions in addition to CD4 and CD8 T-cell interferon-γ responses following COVID-19 mRNA vaccination compared to immunocompetent individuals. Moreover, IS therapy reduced cross-reactivity against SARS-CoV-2 variants. These data suggest that the standard COVID-19 mRNA vaccine regimens will likely not provide optimal protection in immunocompromised individuals. Oxford University Press 2021-11-18 /pmc/articles/PMC8690024/ /pubmed/34792136 http://dx.doi.org/10.1093/infdis/jiab569 Text en © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
| spellingShingle | Major Articles and Brief Reports Collier, Ai-ris Y Yu, Jingyou McMahan, Katherine Liu, Jinyan Atyeo, Caroline Ansel, Jessica L Fricker, Zachary P Pavlakis, Martha Curry, Michael P Jacob-Dolan, Catherine Patel, Het Sellers, Daniel Barrett, Julia Rowe, Marjorie Ahmad, Kunza Gompers, Annika Aguayo, Ricardo Chandrashekar, Abishek Alter, Galit Hacker, Michele R Barouch, Dan H Coronavirus Disease 2019 Messenger RNA Vaccine Immunogenicity in Immunosuppressed Individuals |
| title | Coronavirus Disease 2019 Messenger RNA Vaccine Immunogenicity in Immunosuppressed Individuals |
| title_full | Coronavirus Disease 2019 Messenger RNA Vaccine Immunogenicity in Immunosuppressed Individuals |
| title_fullStr | Coronavirus Disease 2019 Messenger RNA Vaccine Immunogenicity in Immunosuppressed Individuals |
| title_full_unstemmed | Coronavirus Disease 2019 Messenger RNA Vaccine Immunogenicity in Immunosuppressed Individuals |
| title_short | Coronavirus Disease 2019 Messenger RNA Vaccine Immunogenicity in Immunosuppressed Individuals |
| title_sort | coronavirus disease 2019 messenger rna vaccine immunogenicity in immunosuppressed individuals |
| topic | Major Articles and Brief Reports |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8690024/ https://www.ncbi.nlm.nih.gov/pubmed/34792136 http://dx.doi.org/10.1093/infdis/jiab569 |
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