Cargando…

Network analytics for drug repurposing in COVID-19

To better understand the potential of drug repurposing in COVID-19, we analyzed control strategies over essential host factors for SARS-CoV-2 infection. We constructed comprehensive directed protein–protein interaction (PPI) networks integrating the top-ranked host factors, the drug target proteins...

Descripción completa

Detalles Bibliográficos
Autores principales:	Siminea, Nicoleta, Popescu, Victor, Sanchez Martin, Jose Angel, Florea, Daniela, Gavril, Georgiana, Gheorghe, Ana-Maria, Iţcuş, Corina, Kanhaiya, Krishna, Pacioglu, Octavian, Popa, Laura Ioana, Trandafir, Romica, Tusa, Maria Iris, Sidoroff, Manuela, Păun, Mihaela, Czeizler, Eugen, Păun, Andrei, Petre, Ion
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Problem Solving Protocol
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8690228/ https://www.ncbi.nlm.nih.gov/pubmed/34864885 http://dx.doi.org/10.1093/bib/bbab490

Ejemplares similares

Validation of transcriptome signature reversion for drug repurposing in oncology
por: Koudijs, Karel K M, et al.
Publicado: (2022)

Vir2Drug: a drug repurposing framework based on protein similarities between pathogens
por: Minadakis, George, et al.
Publicado: (2022)

Network controllability solutions for computational drug repurposing using genetic algorithms
por: Popescu, Victor-Bogdan, et al.
Publicado: (2022)

BindingSite-AugmentedDTA: enabling a next-generation pipeline for interpretable prediction models in drug repurposing
por: Yousefi, Niloofar, et al.
Publicado: (2023)

Multi-omics data integration and network-based analysis drives a multiplex drug repurposing approach to a shortlist of candidate drugs against COVID-19
por: Tomazou, Marios, et al.
Publicado: (2021)

Pleuritic Chest Pain; Where Should We Search for?
por: Gharib, Behdad, et al.
Publicado: (2011)

A young man with multiple joint pains and fever: A case with the importance of accurate history taking
por: Sonoda, Kento, et al.
Publicado: (2017)

A 16-year odyssey of cardiac sarcoid masquerading as idiopathic premature ventricular contractions and then arrhythmogenic cardiomyopathy
por: Nakamura, Tomofumi, et al.
Publicado: (2018)

Bundle branch reentry with His dissociation—The His bundle: Bystander or participant?
por: Nageh, Maged F., et al.
Publicado: (2018)

Intermittent loss of capture in a His bundle pacemaker: What is the cause?
por: Padala, Santosh K., et al.
Publicado: (2017)

Impact of a novel algorithm designed to reduce T-wave oversensing with the subcutaneous defibrillator in a patient with type I Brugada electrocardiogram
por: Boveda, Serge, et al.
Publicado: (2017)

Pitfalls of pacemaker detection of ventricular high-rate events
por: Mansour, Fadi, et al.
Publicado: (2018)

Beauty and the beat: A complicated case of multifocal ectopic Purkinje-related premature contractions
por: ter Bekke, Rachel M.A., et al.
Publicado: (2018)

Successful transseptal puncture and cryoballoon ablation of symptomatic paroxysmal atrial fibrillation via jugular access in a patient with bilateral thrombotic femoral vein occlusion
por: Kox, Thomas, et al.
Publicado: (2019)

Cardiac implantable electronic device malfunction after deceleration injury without obvious chest trauma
por: Barakat, Amr F., et al.
Publicado: (2019)

Clinical problem solving: Maneuvering around a narrow complex tachycardia in a patient with Mustard repair for transposition of the great arteries
por: Jackson, Nicholas, et al.
Publicado: (2016)

Parasternal intercostal approach as an alternative to subxiphoid approach for epicardial catheter ablation: A case report
por: Miyamoto, Koji, et al.
Publicado: (2015)

An unusual ICD shock: What is the mechanism?
por: Gopinathannair, Rakesh, et al.
Publicado: (2015)

Wide complex tachycardia in a patient with pre-excitation: What is the mechanism?
por: Yeo, Colin, et al.
Publicado: (2017)

Tachycardia-induced cardiomyopathy long after a pacemaker implantation for the treatment of unusual 2:1 atrioventricular block: What is the mechanism?
por: Sairaku, Akinori, et al.
Publicado: (2015)

All that glitters is not gold
por: Mizumoto, Junki, et al.
Publicado: (2019)

Cardioneuroablation for management of cardioinhibitory vasovagal syncope and pacemaker complications
por: Stec, Sebastian, et al.
Publicado: (2020)

Protein functional annotation of simultaneously improved stability, accuracy and false discovery rate achieved by a sequence-based deep learning
por: Hong, Jiajun, et al.
Publicado: (2019)

Clinical trials, progression-speed differentiating features and swiftness rule of the innovative targets of first-in-class drugs
por: Li, Ying Hong, et al.
Publicado: (2019)

ANPELA: analysis and performance assessment of the label-free quantification workflow for metaproteomic studies
por: Tang, Jing, et al.
Publicado: (2019)

CAFU: a Galaxy framework for exploring unmapped RNA-Seq data
por: Chen, Siyuan, et al.
Publicado: (2019)

Virus-CKB: an integrated bioinformatics platform and analysis resource for COVID-19 research
por: Feng, Zhiwei, et al.
Publicado: (2020)

MolAICal: a soft tool for 3D drug design of protein targets by artificial intelligence and classical algorithm
por: Bai, Qifeng, et al.
Publicado: (2020)

New insights on human essential genes based on integrated analysis and the construction of the HEGIAP web-based platform
por: Chen, Hebing, et al.
Publicado: (2019)

A comprehensive method protocol for annotation and integrated functional understanding of lncRNAs
por: Kunz, Meik, et al.
Publicado: (2019)

Bipolar ablation of high-risk posteroseptal accessory pathway: Back to the future
por: Futyma, Piotr, et al.
Publicado: (2019)

An efficient multi-locus mixed model framework for the detection of small and linked QTLs in F(2)
por: Wen, Yang-Jun, et al.
Publicado: (2018)

Revealing tumor heterogeneity of breast cancer by utilizing the linkage between somatic and germline mutations
por: Zou, Meng, et al.
Publicado: (2018)

Protein–peptide docking using CABS-dock and contact information
por: Blaszczyk, Maciej, et al.
Publicado: (2018)

Why‐not‐doing‐high‐tech‐test Syndrome
por: Mizumoto, Junki, et al.
Publicado: (2020)

Regression on imperfect class labels derived by unsupervised clustering
por: Brøndum, Rasmus Froberg, et al.
Publicado: (2020)

Toward a gold standard for benchmarking gene set enrichment analysis
por: Geistlinger, Ludwig, et al.
Publicado: (2020)

Hybrid modelling of biological systems using fuzzy continuous Petri nets
por: Liu, Fei, et al.
Publicado: (2019)

A novel bioinformatics approach to identify the consistently well-performing normalization strategy for current metabolomic studies
por: Yang, Qingxia, et al.
Publicado: (2019)

A comparative study of multi-omics integration tools for cancer driver gene identification and tumour subtyping
por: Sathyanarayanan, Anita, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_b1911lcf3dsdr5bdaf46l2dp23