Melodinines Y(1)–Y(4), four monoterpene indole alkaloids from Melodinus henryi

Melodinines Y(1)–Y(4) (1–4), four undescribed alkaloids were isolated from Melodinus henryi. Their structures were elucidated by extensive NMR, mass spectroscopic analyses, theoretical NMR and electronic circular dichroism (ECD) calculations. Compounds 1 and 2 are the first examples of bisindole alk...

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Detalles Bibliográficos
Autores principales: Zhang, Fa-Lei, He, Juan, Feng, Tao, Liu, Ji-Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8690234/
https://www.ncbi.nlm.nih.gov/pubmed/35423052
http://dx.doi.org/10.1039/d0ra09819a
Descripción
Sumario:Melodinines Y(1)–Y(4) (1–4), four undescribed alkaloids were isolated from Melodinus henryi. Their structures were elucidated by extensive NMR, mass spectroscopic analyses, theoretical NMR and electronic circular dichroism (ECD) calculations. Compounds 1 and 2 are the first examples of bisindole alkaloids possessing an eburnamine–leuconoxine combination. Compound 3 is a rare 2,3-seco pleiocarpamine type monoterpene indole alkaloid. Compound 1 showed cytotoxic activities against six human cancer cell lines with IC(50) values of 0.5–15.2 μM.

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