Melodinines Y(1)–Y(4), four monoterpene indole alkaloids from Melodinus henryi

Melodinines Y(1)–Y(4) (1–4), four undescribed alkaloids were isolated from Melodinus henryi. Their structures were elucidated by extensive NMR, mass spectroscopic analyses, theoretical NMR and electronic circular dichroism (ECD) calculations. Compounds 1 and 2 are the first examples of bisindole alk...

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Autores principales: Zhang, Fa-Lei, He, Juan, Feng, Tao, Liu, Ji-Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8690234/
https://www.ncbi.nlm.nih.gov/pubmed/35423052
http://dx.doi.org/10.1039/d0ra09819a
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author Zhang, Fa-Lei
He, Juan
Feng, Tao
Liu, Ji-Kai
author_facet Zhang, Fa-Lei
He, Juan
Feng, Tao
Liu, Ji-Kai
author_sort Zhang, Fa-Lei
collection PubMed
description Melodinines Y(1)–Y(4) (1–4), four undescribed alkaloids were isolated from Melodinus henryi. Their structures were elucidated by extensive NMR, mass spectroscopic analyses, theoretical NMR and electronic circular dichroism (ECD) calculations. Compounds 1 and 2 are the first examples of bisindole alkaloids possessing an eburnamine–leuconoxine combination. Compound 3 is a rare 2,3-seco pleiocarpamine type monoterpene indole alkaloid. Compound 1 showed cytotoxic activities against six human cancer cell lines with IC(50) values of 0.5–15.2 μM.
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spelling pubmed-86902342022-04-13 Melodinines Y(1)–Y(4), four monoterpene indole alkaloids from Melodinus henryi Zhang, Fa-Lei He, Juan Feng, Tao Liu, Ji-Kai RSC Adv Chemistry Melodinines Y(1)–Y(4) (1–4), four undescribed alkaloids were isolated from Melodinus henryi. Their structures were elucidated by extensive NMR, mass spectroscopic analyses, theoretical NMR and electronic circular dichroism (ECD) calculations. Compounds 1 and 2 are the first examples of bisindole alkaloids possessing an eburnamine–leuconoxine combination. Compound 3 is a rare 2,3-seco pleiocarpamine type monoterpene indole alkaloid. Compound 1 showed cytotoxic activities against six human cancer cell lines with IC(50) values of 0.5–15.2 μM. The Royal Society of Chemistry 2020-12-22 /pmc/articles/PMC8690234/ /pubmed/35423052 http://dx.doi.org/10.1039/d0ra09819a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Zhang, Fa-Lei
He, Juan
Feng, Tao
Liu, Ji-Kai
Melodinines Y(1)–Y(4), four monoterpene indole alkaloids from Melodinus henryi
title Melodinines Y(1)–Y(4), four monoterpene indole alkaloids from Melodinus henryi
title_full Melodinines Y(1)–Y(4), four monoterpene indole alkaloids from Melodinus henryi
title_fullStr Melodinines Y(1)–Y(4), four monoterpene indole alkaloids from Melodinus henryi
title_full_unstemmed Melodinines Y(1)–Y(4), four monoterpene indole alkaloids from Melodinus henryi
title_short Melodinines Y(1)–Y(4), four monoterpene indole alkaloids from Melodinus henryi
title_sort melodinines y(1)–y(4), four monoterpene indole alkaloids from melodinus henryi
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8690234/
https://www.ncbi.nlm.nih.gov/pubmed/35423052
http://dx.doi.org/10.1039/d0ra09819a
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