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New Trends and Most Promising Therapeutic Strategies for Epilepsy Treatment

Background: Despite the wide availability of novel anti-seizure medications (ASMs), 30% of patients with epilepsy retain persistent seizures with a significant burden in comorbidity and an increased risk of premature death. This review aims to discuss the therapeutic strategies, both pharmacological...

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Autores principales: Riva, Antonella, Golda, Alice, Balagura, Ganna, Amadori, Elisabetta, Vari, Maria Stella, Piccolo, Gianluca, Iacomino, Michele, Lattanzi, Simona, Salpietro, Vincenzo, Minetti, Carlo, Striano, Pasquale
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8690245/
https://www.ncbi.nlm.nih.gov/pubmed/34950099
http://dx.doi.org/10.3389/fneur.2021.753753
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author Riva, Antonella
Golda, Alice
Balagura, Ganna
Amadori, Elisabetta
Vari, Maria Stella
Piccolo, Gianluca
Iacomino, Michele
Lattanzi, Simona
Salpietro, Vincenzo
Minetti, Carlo
Striano, Pasquale
author_facet Riva, Antonella
Golda, Alice
Balagura, Ganna
Amadori, Elisabetta
Vari, Maria Stella
Piccolo, Gianluca
Iacomino, Michele
Lattanzi, Simona
Salpietro, Vincenzo
Minetti, Carlo
Striano, Pasquale
author_sort Riva, Antonella
collection PubMed
description Background: Despite the wide availability of novel anti-seizure medications (ASMs), 30% of patients with epilepsy retain persistent seizures with a significant burden in comorbidity and an increased risk of premature death. This review aims to discuss the therapeutic strategies, both pharmacological and non-, which are currently in the pipeline. Methods: PubMed, Scopus, and EMBASE databases were screened for experimental and clinical studies, meta-analysis, and structured reviews published between January 2018 and September 2021. The terms “epilepsy,” “treatment” or “therapy,” and “novel” were used to filter the results. Conclusions: The common feature linking all the novel therapeutic approaches is the spasmodic rush toward precision medicine, aiming at holistically evaluating patients, and treating them accordingly as a whole. Toward this goal, different forms of intervention may be embraced, starting from the choice of the most suitable drug according to the type of epilepsy of an individual or expected adverse effects, to the outstanding field of gene therapy. Moreover, innovative insights come from in-vitro and in-vivo studies on the role of inflammation and stem cells in the brain. Further studies on both efficacy and safety are needed, with the challenge to mature evidence into reliable assets, ameliorating the symptoms of patients, and answering the challenges of this disease.
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spelling pubmed-86902452021-12-22 New Trends and Most Promising Therapeutic Strategies for Epilepsy Treatment Riva, Antonella Golda, Alice Balagura, Ganna Amadori, Elisabetta Vari, Maria Stella Piccolo, Gianluca Iacomino, Michele Lattanzi, Simona Salpietro, Vincenzo Minetti, Carlo Striano, Pasquale Front Neurol Neurology Background: Despite the wide availability of novel anti-seizure medications (ASMs), 30% of patients with epilepsy retain persistent seizures with a significant burden in comorbidity and an increased risk of premature death. This review aims to discuss the therapeutic strategies, both pharmacological and non-, which are currently in the pipeline. Methods: PubMed, Scopus, and EMBASE databases were screened for experimental and clinical studies, meta-analysis, and structured reviews published between January 2018 and September 2021. The terms “epilepsy,” “treatment” or “therapy,” and “novel” were used to filter the results. Conclusions: The common feature linking all the novel therapeutic approaches is the spasmodic rush toward precision medicine, aiming at holistically evaluating patients, and treating them accordingly as a whole. Toward this goal, different forms of intervention may be embraced, starting from the choice of the most suitable drug according to the type of epilepsy of an individual or expected adverse effects, to the outstanding field of gene therapy. Moreover, innovative insights come from in-vitro and in-vivo studies on the role of inflammation and stem cells in the brain. Further studies on both efficacy and safety are needed, with the challenge to mature evidence into reliable assets, ameliorating the symptoms of patients, and answering the challenges of this disease. Frontiers Media S.A. 2021-12-07 /pmc/articles/PMC8690245/ /pubmed/34950099 http://dx.doi.org/10.3389/fneur.2021.753753 Text en Copyright © 2021 Riva, Golda, Balagura, Amadori, Vari, Piccolo, Iacomino, Lattanzi, Salpietro, Minetti and Striano. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Riva, Antonella
Golda, Alice
Balagura, Ganna
Amadori, Elisabetta
Vari, Maria Stella
Piccolo, Gianluca
Iacomino, Michele
Lattanzi, Simona
Salpietro, Vincenzo
Minetti, Carlo
Striano, Pasquale
New Trends and Most Promising Therapeutic Strategies for Epilepsy Treatment
title New Trends and Most Promising Therapeutic Strategies for Epilepsy Treatment
title_full New Trends and Most Promising Therapeutic Strategies for Epilepsy Treatment
title_fullStr New Trends and Most Promising Therapeutic Strategies for Epilepsy Treatment
title_full_unstemmed New Trends and Most Promising Therapeutic Strategies for Epilepsy Treatment
title_short New Trends and Most Promising Therapeutic Strategies for Epilepsy Treatment
title_sort new trends and most promising therapeutic strategies for epilepsy treatment
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8690245/
https://www.ncbi.nlm.nih.gov/pubmed/34950099
http://dx.doi.org/10.3389/fneur.2021.753753
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