450. Type I Interferon Autoantibodies Are Detected in Those with Critical COVID-19, Including a Young Female Patient

BACKGROUND: Approximately 10-20% of patients with critical COVID-19 harbor neutralizing autoantibodies (auto-Abs) that target type I interferons (IFN), a family of cytokines that induce critical innate immune defense mechanisms upon viral infection. Studies to date indicate that these auto-Abs are m...

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Detalles Bibliográficos
Autores principales: Yee, Debra, Tso, Marana, Shaw, Elana, Rosen, Lindsey B, Samuels, Emily, Bastard, Paul, Casanova, Jean-Laurent, Holland, Steven M, Su, Helen C, Richard, Stephanie A, Mende, Katrin, Lalani, Tahaniyat, Lindholm, David A, Simons, Mark P, Tribble, David, Malloy, Allison, Laing, Eric, Agan, Brian, Pollett, Simon, Burgess, Timothy, Snow, Andrew L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Poster Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8690641/
http://dx.doi.org/10.1093/ofid/ofab466.649

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