Cargando…

HIF-1α switches the functionality of TGF-β signaling via changing the partners of smads to drive glucose metabolic reprogramming in non-small cell lung cancer

BACKGROUND: Most cancer cells have fundamentally different metabolic characteristics, particularly much higher glycolysis rates than normal tissues, which support the increased demand for biosynthesis and promote tumor progression. We found that transforming growth factor (TGF)-β plays a dual functi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Yiwei, Chen, Zhencong, Lu, Tao, Bi, Guoshu, Li, Ming, Liang, Jiaqi, Hu, Zhengyang, Zheng, Yuansheng, Yin, Jiacheng, Xi, Junjie, Lin, Zongwu, Zhan, Cheng, Jiang, Wei, Wang, Qun, Tan, Lijie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8690885/ https://www.ncbi.nlm.nih.gov/pubmed/34930376 http://dx.doi.org/10.1186/s13046-021-02188-y

Ejemplares similares

Cisplatin resistance-related multi-omics differences and the establishment of machine learning models
por: Sui, Qihai, et al.
Publicado: (2022)

Genetic and microenvironmental differences in non-smoking lung adenocarcinoma patients compared with smoking patients
por: Sui, Qihai, et al.
Publicado: (2020)

Dissecting the single-cell transcriptome network in patients with esophageal squamous cell carcinoma receiving operative paclitaxel plus platinum chemotherapy
por: Chen, Zhencong, et al.
Publicado: (2021)

LncRNA FAM83A-AS1 facilitates tumor proliferation and the migration via the HIF-1α/ glycolysis axis in lung adenocarcinoma
por: Chen, Zhencong, et al.
Publicado: (2022)

Landscape and dynamics of single tumor and immune cells in early and advanced‐stage lung adenocarcinoma
por: Chen, Zhencong, et al.
Publicado: (2021)

Enlarged Mediastinal Lymph Nodes in Computed Tomography are a Valuable Prognostic Factor in Non-Small Cell Lung Cancer Patients with Pathologically Negative Lymph Nodes
por: Zheng, Yuansheng, et al.
Publicado: (2020)

Single-cell transcriptome atlas of lung adenocarcinoma featured with ground glass nodules
por: Lu, Tao, et al.
Publicado: (2020)

Reconstructing the Developmental Trajectories of Multiple Subtypes in Pulmonary Parenchymal Epithelial Cells by Single-Cell RNA-seq
por: Huang, Yiwei, et al.
Publicado: (2020)

miR-6077 promotes cisplatin/pemetrexed resistance in lung adenocarcinoma via CDKN1A/cell cycle arrest and KEAP1/ferroptosis pathways
por: Bi, Guoshu, et al.
Publicado: (2022)

Ligand-receptor interaction atlas within and between tumor cells and T cells in lung adenocarcinoma
por: Chen, Zhencong, et al.
Publicado: (2020)

A nomogram to predict prognosis of patients with lung adenosquamous carcinoma: a population-based study
por: Liang, Jiaqi, et al.
Publicado: (2020)

The clinical prognostic factors of patients with stage IB lung adenocarcinoma
por: Sui, Qihai, et al.
Publicado: (2021)

Clinicopathological features and prognosis of patients with esophageal cancer as the second primary cancer: a large population-based analysis using the SEER program [2000–2015]
por: Chen, Zhencong, et al.
Publicado: (2020)

Identification of the relationship between single-cell N6-methyladenosine regulators and the infiltrating immune cells in esophageal carcinoma
por: Bian, Yunyi, et al.
Publicado: (2023)

Signatures of malignant cells and novel therapeutic targets revealed by single‐cell sequencing in lung adenocarcinoma
por: Liang, Jiaqi, et al.
Publicado: (2022)

Integrated analysis of patients with KEAP1/NFE2L2/CUL3 mutations in lung adenocarcinomas
por: Jin, Xing, et al.
Publicado: (2021)

The genomic signature of resistance to platinum-containing neoadjuvant therapy based on single-cell data
por: Sui, Qihai, et al.
Publicado: (2023)

Correction to: The genomic signature of resistance to platinum-containing neoadjuvant therapy based on single-cell data
por: Sui, Qihai, et al.
Publicado: (2023)

Identification and analysis of a prognostic ferroptosis and iron-metabolism signature for esophageal squamous cell carcinoma
por: Zhao, Mengnan, et al.
Publicado: (2022)

Clinicopathological and prognostic implications of ALK rearrangement in patients with completely surgically resected lung adenocarcinoma
por: Zhang, Huan, et al.
Publicado: (2021)

Differences in genetics and microenvironment of lung adenocarcinoma patients with or without TP53 mutation
por: Zeng, Dejun, et al.
Publicado: (2021)

Multi-omics characterization and validation of invasiveness-related molecular features across multiple cancer types
por: Bi, Guoshu, et al.
Publicado: (2021)

Prognostic Impact of Radiological Consolidation Tumor Ratio in Clinical Stage IA Pulmonary Ground Glass Opacities
por: Xi, Junjie, et al.
Publicado: (2021)

Pan-cancer characterization of metabolism-related biomarkers identifies potential therapeutic targets
por: Bi, Guoshu, et al.
Publicado: (2021)

Dissecting the single-cell transcriptome network underlying esophagus non-malignant tissues and esophageal squamous cell carcinoma
por: Chen, Zhencong, et al.
Publicado: (2021)

HNF4G increases cisplatin resistance in lung adenocarcinoma via the MAPK6/Akt pathway
por: Liang, Jiaqi, et al.
Publicado: (2023)

Hepatic nuclear factor 4 alpha promotes the ferroptosis of lung adenocarcinoma via transcriptional activation of cytochrome P450 oxidoreductase
por: Besskaya, Valeria, et al.
Publicado: (2023)

Development and validation of a nomogram for predicting the overall survival of patients with lung large cell neuroendocrine carcinoma
por: Xi, Junjie, et al.
Publicado: (2020)

Analysis of the differences in lung cancer research trends between China and the United States based using project funding data
por: Zheng, Yuansheng, et al.
Publicado: (2021)

Identification and validation of the mitochondrial function related hub genes by unsupervised machine learning and multi-omics analyses in lung adenocarcinoma
por: Jin, Xing, et al.
Publicado: (2022)

Dissecting the single-cell transcriptome network of macrophage and identifies a signature to predict prognosis in lung adenocarcinoma
por: Hu, Zhengyang, et al.
Publicado: (2023)

Multinomial and ordinal Logistic regression analyses with multi-categorical variables using R
por: Liang, Jiaqi, et al.
Publicado: (2020)

Long-term outcomes following neoadjuvant or adjuvant chemoradiotherapy for stage I–IIIA non-small cell lung cancer: a propensity-matched analysis
por: Xi, Junjie, et al.
Publicado: (2020)

Characterization of Infiltrating Immune Cells and Secretory or Membrane-Associated Proteins in KRAS Lung Adenocarcinoma
por: Bian, Yunyi, et al.
Publicado: (2023)

Knockdown of GTF2E2 inhibits the growth and progression of lung adenocarcinoma via RPS4X in vitro and in vivo
por: Bi, Guoshu, et al.
Publicado: (2021)

Compare the efficacy and safety of programmed cell death-1 (PD-1) and programmed cell death ligand-1 (PD-L1) inhibitors for advanced non-small cell lung cancer: a Bayesian analysis
por: Liang, Jiaqi, et al.
Publicado: (2020)

Risk and prognostic nomograms for hepatocellular carcinoma with newly-diagnosed pulmonary metastasis using SEER data
por: Ye, Guanzhi, et al.
Publicado: (2019)

Analysis of the clinicopathological characteristics, genetic phenotypes, and prognostic of pure mucinous adenocarcinoma
por: Chen, Zhencong, et al.
Publicado: (2019)

Solid component ratio influences prognosis of GGO-featured IA stage invasive lung adenocarcinoma
por: Sun, Fenghao, et al.
Publicado: (2020)

Hierarchy of TGFβ/SMAD, Hippo/YAP/TAZ, and Wnt/β-catenin signaling in melanoma phenotype switching
por: Lüönd, Fabiana, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_q431nd7tkk207ka7t3a1tnhbgc